Not to be confused with the active item, IV Bag.
A plastic bag, full of blood.
Isaac gets blood all over his mouth, with his teeth becoming crooked.
- The Blood Bag has a 1/30 chance of being dropped by a Blood Donation Machine per play if you have not picked up the IV Bag.
- The chances are 1/15 to drop a Blood Bag if you have already picked up the IV Bag.
- The Blood Bag and A Dollar rewards can be re-rolled with The Dice.
- This item can be won and picked up multiple times during one playthrough.
- The Blood Bag does not restore any hearts for ???, it only adds a Soul Heart.
- Isaac's mouth bears resemblance to Larry Jr.'s after picking up this item.
- After a Blood Donation Machine explodes, the Blood Bag's sprite can be replaced by the sprite of the Sad Onion for a few frames.