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Items are an integral part of gameplay in The Binding of Isaac. They modify a character's stats, grant or modify abilities, and many other things.

Items in general are classified into a number of distinct types and groups. Some items are passive, which add an effect permanently to Isaac, while others only activate when used.

Items dropped in the Binding of Isaac NEVER disappear over time; a coin dropped will remain where it was dropped until you pick it up or leave the floor. A dropped item can be left in its place to be collected at a later time.

Among these types are:

Activated ItemsModifier

Activated Items fill your spacebar slot. Only one can be carried at a time. An activated item can be used by pressing space, and unlike a pill or card, activated items recharge over time and can be reused when ready. Each item has a unique effect. Most activated items can only appear once per game with few exceptions, so leaving behind an activated item is typically a permanent choice.


These Items, when picked up, add a permanent effect to Isaac. These cannot be removed and are individually counted on the collection screen. Collectible items can be obtained in a variety of ways and most are unique in that, once appearing in game, they will never appear again during that session.


These go into your Q slot and are one-time-use items. There are a number of different pill styles and effects. At the start of the game, each type is randomly assigned an effect, which remains bound to that pill style for the remainder of that game. Pills start unidentified and are identified once used, unless the player has the PHD item, which identifies pills after a short delay. Picking up a pill or card while you already have one causes the old one to be dropped.

Tarot CardsModifier

Tarot Cards are also Q slot items, and are also one-time use. Tarot Cards are unidentified when dropped and immediately identified when picked up. Each card has a unique and pre-determined effect. Picking up a pill or card while already carrying one causes the old one to be dropped.


Trinkets fill their own slot and are passive items that affect Isaac in unique ways. Only one can be carried at a time (Unless the player has Mom's Purse, which allows Isaac to hold two Trinkets at once); taking another will replace the current trinket and drop the old one.

Pick UpsModifier

These are common items dropped in game and, when taken automatically confer their effect. This category includes items such as coins, hearts, keys and bombs and disappear once picked up.


There are 198 different collectible items in the game. Below is a list of all of the collectibles, separated into categories. Certain collectibles change the appearance of your character when they are acquired. Collectibles you've found can be seen in the Collection page.

Activated CollectiblesModifier

These items are stored in the Spacebar slot and are used up once the button is pressed. The items then recharge in one of two ways. Normally, they charge a number of bars after every room you clear—some items charge one bar at a time, others charge faster. Note that only rooms where the doors close until they are cleared count—Bosses, arenas, enemy rooms, etc. The Collectible Item "Battery" can give bars of charge during combat, on top of the normal recharge. Another Collectible Item, the "9 Volt", will automatically recharge 2 bars when an item is used; this effectively reduces the number of rooms required to charge an item if the item requires 3 or more rooms to charge. In the Wrath of the Lamb DLC, there is another item, the Habit, which will recharge bars when taking damage. To see a clearer version of the in-game arrangement, go to the Collection page.

Note: Any two of the same activated item on the same floor will share charge state, i.e. Finding another of the same activated item when one is not fully charged will not give the player another fully charged version of the item. This can be observed in the Library, which can spawn 2 of the same book.

Objet Icône Effet Recharge Time
Anarchist Cookbook Anarchist Cookbook Icon

Spawns six troll bombs around the room.

The Bean The Bean Icon

Causes Isaac to have bad gas, poisoning any enemy in close vicinity.

Bob's Rotten Head Bobs Rotten Head Icon

Throws a bomb in the direction Isaac's facing. It does extreme damage, poisons the enemy for 5 seconds, and destroys rocks.

The Bible The Bible Icon

Upon activation, Isaac gains Flight, allowing him to pass over all obstacles in the current room. Instantly kills Mom, Mom's Heart and It Lives when activated, will kill Isaac when activated while fighting Satan, Isaac or ??? unless he has The Wafer.

The Book Of Belial The Book Of Belial Icon

Adds 2 points of damage for the current room. Damage is further multiplied by 1.5x with the Blood Of The Martyr item. Also increases chances of a Devil Room spawning by 25%.

Book Of Revelations Book Of Revelations Icon

Adds 1 Soul Heart and makes the next boss a Horseman (except on XL Floors and on floors with fixed bosses such as Mom). Increases chances of a Devil Room spawning by 35%.

Book Of Shadows Book Of Shadows Icon

Grants Isaac invulnerability for 10 seconds.

The Book Of Sin The Book Of Sin Icon

Spawns a random Pick Up, Pill or Card.

Dead Sea Scrolls Dead Sea Scrolls Icon

Uses a random Activated Item.

Deck of Cards Deck Of Cards Icon

Gives Isaac a random Tarot Card.

The Dice The Dice Icon

Allows Isaac to re-roll collectible items in the current room into other items, depending on the current room's Item Pool.

Doctor's Remote Doctors Remote Icon

Sets a big red target on the ground (similar to the Epic Fetus item) which can be controlled with the arrow keys or the mouse. After 6 seconds or by pressing space again, a huge explosive missile hits it, which damages all enemies caught in its blast radius.

Forget Me Now Forget Me Now Icon

When activated, the level ends and is freshly regenerated with new rooms, monsters, and items. Disappears after use.

One-time use
The Gamekid The Gamekid Icon

Isaac turns into a Pac-Man-like creature for 5 seconds, gaining invincibility, +0.28 Speed, and the ability to damage enemies by touch, restoring a half-heart of health for every 2 enemies killed. Enemies will also turn blue and start fleeing from Isaac for the duration of the effect.

The Hourglass The Hourglass Icon

Upon activation, enemies and their projectiles are slowed down for 7.67 seconds.

Kamikaze! Kamikaze Icon

Creates an explosion in the same area as Isaac, dealing one heart of damage to him and also damaging all enemies caught in the blast radius.

Lemon Mishap 35px

Creates a small yellow pool of Creep, which damages enemies that cross it.

Mom's Bottle Of Pills 40px

Gives Isaac a random Pill, and will cause him to drop any held Q-slot item (If any). The player will only receive six different pill types in one playthrough.

Mom's Bra 40px

Causes Isaac to wear a bra on his head for a short period of time, which freezes enemies for 5 seconds.

Mom's Pad 25px

Causes enemies to back away from Isaac for 5 seconds.

Monster Manuel 40px

Summons a random familiar for the current room only, even if it is locked.

Monstro's Tooth 30px

Monstro jumps onto a random enemy, doing damage. Cannot be used in a fight against Monstro, but can be used against Monstro II.

Mr. Boom 40px

Drops a large bomb.

My Little Unicorn My Little Unicorn Icon

Grants Isaac invincibility for a short period of time. Isaac cannot fire tears during the invincibility effect, but he can damage enemies by touch. Increases Speed by 0.28 for the duration of the effect.

The Nail The Nail Icon

Adds one Soul Heart and allows the breaking of Rocks and damaging enemies by simply walking over them.

Increases Damage by 0.7 and decreases Speed by 0.18.

The Necronomicon The Necronomicon Icon

Damages all enemies in the room significantly.

A Pony A Pony Icon

Upon use, Isaac will charge in the direction selected, and will become invincible during the charge, allowing him to damage enemies by touch.
While equipped, passively increases Speed to a minimum of 1.5, and grants Isaac Flight.

The Poop The Poop Icon

Drops a pile of poop at his current location. This pile of poop may yield Hearts or Coins like regular poop.

Razor Blade Razor Blade Icon

Deals 1 Heart of damage to Isaac, which increases damage for the current room.

The Pinking Shears 40px

Separates Isaac's head and body for the current room. Isaac's head will be controlled, which now has Flight, while his body will seek out enemies to attack by contact damage.

Shoop Da Whoop! Shoop Da Whoop Icon

Fires a laser from Isaac's mouth.

Tammy's Head 40px

Shoots 10 tears in a circle around Isaac, which retain the size (damage), shot speed, and special effects (such as Poison) of Isaac's tears. The tears are not affected by tear-replacing items like Brimstone.

Teleport! Teleport Icon

Teleports Isaac to a random room on the current floor.

We Need To Go Deeper! We Need To Go Deeper Icon

Creates a trapdoor to go to the next floor. If used in The Womb, it will create a trapdoor to Sheol, even if the player hasn't unlocked it.
Does not work in Sheol, The Cathedral, or The Chest.

Yum Heart Yum Heart Icon

Restores 1 whole heart.


Wrath of the Lamb Activated CollectiblesModifier

The following activated items can only be acquired in the Wrath of the Lamb DLC.

Objet Icône Effet Recharge Time

Best Friend

Best Friend Icon

Deploys a decoy Isaac that eventually explodes with an increased blast radius.

Like all explosive attacks, the explosion can hurt Isaac if he is within the blast radius.

Blood Rights Blood Rights Icon

Deals a half-heart of damage to Isaac, which damages all enemies in the room.


The Candle

The Candle Icon

Throws out a blue flame that can pass over gaps (but not through rocks) that damages anything in its path.

Recharges 3 seconds after firing.

Recharges itself

Crack The Sky

Crack The Sky Icon

Summons multiple beams of light in random locations around the room, dealing a large amount of damage to any enemy that touches them.

Crystal Ball Crystal Ball Icon

Reveals the map and drops a random Tarot Card or Soul Heart.



D20 Icon

Randomly changes all Pick Ups in the current room.


Dad's Key

Dads Key Icon

Opens all doors in the current room when activated, except rooms which require a Key to open, such as Treasure Rooms and Libraries.


Guppy's Head


Spawns 2-4 Blue Flies to damage enemies.


Guppy's Paw


Removes one Heart Container in exchange for gaining 3 Soul Hearts.


IV Bag


Upon activation, Isaac loses a half-heart (one whole heart in The Womb and onwards) for a random amount of coins, similar to the Blood Donation Machine.


Notched Axe

Notched Axe Icon

Breaks a single rock when activated.


Portable Slot


Upon activation, 1 coin will be consumed, and a random Pick Up may drop, similar to the Slot Machine.


Prayer Card

Prayer Card Icon

Grants half an Eternal Heart per use.


Remote Detonator

Remote Detonator Icon

Bombs you place explode only when you use this item.

Gives 5 bombs.


Spider Butt

Spider Butt Icon

Damages all enemies in the room and and slows them and their projectiles down for 2.5 seconds (similar to The Hourglass).


Telepathy For Dummies


Gives Isaac homing tears for the current room. (Identical to Spoon Bender)


White Pony


Upon use, Isaac will become invincible and charge in the direction selected, dealing damage to monsters touched. In addition, beams of light (similar to Crack The Sky) drop down in random locations around the room, damaging any enemies that touch them.

While equipped, increases Speed up to a minimum of 1.5, and grants Isaac Flight.


Rebirth Activated CollectiblesModifier

The following activated items were added in The Binding of Isaac: Rebirth.

Objet Icône Effet Recharge Time
Butter Bean Rebirth butter bean

Knockbacks all enemies on use

Boomerang Image required

Throws a boomerang that damages and petrifies enemies.

Recharges itself
Butter Bean Rebirth butter bean

Knockbacks all enemies on use

Converter Converter Icon

Converts soul hearts into heart containers.

Isaac's Tears Isaac's Tears Icon

Shoots a burst of tears in eight directions.
Recharges automatically as Isaac shoots normal tears.

6 tears shot

Passive CollectiblesModifier

These items generally give you some kind of a boost to your stats, or add a special passive ability. They take effect immediately once picked up, and continue for the rest of the game (except for several items that do not provide any lasting effect).

Edmund McMillen split them up in his blog into the subcategories "weapon items" (Such as Number One), "stat padding items" (Such as Growth Hormones), "passive items" (Such as Mitre), and Familiars (Such as Little Gish).

Objet Icône Effet



Increases available heart containers by 1 and restores all health.



Gives an extra life. Upon death, you will respawn in the previous room with full health and lose the 1UP.

9 Volt

9 Volt Icon

Leaves Isaac with two bars already charged after using an item.

Upon pickup, Isaac's current activated item will be fully charged.

The Battery

The Battery Icon

Gives Isaac an extra charge every 15 seconds per room, up to a maximum of 3 charges.

The Belt

The Belt Icon

Increases Speed by 2.

Blood Bag


Increases HP by 1, Speed by 0.3, and restores 4 hearts.

More than one can be obtained during a same playthrough

Blood Of The Martyr


Increases Damage by 1, and turns Isaac's tears into blood tears. If collected with the The Book of Belial, damage will also be multiplied by 1.5x upon activation.



Gives Isaac 5 Bombs, and causes all dropped bombs to home towards the closest enemy.

Bomb Bag

Bomb Bag Icon

Isaac is followed by a small bag that drops a Bomb, 1+1 Free, or a Troll Bomb every 3 rooms.



Gives 10 bombs.


Breakfast Icon

Increases HP by 1.



Changes tears to a chargeable laser, which pierces all objects in its path. Also multiplies damage by 3.

It can only be fired after a short charge-up period.

Brother Bobby

Brother Bobby Icon

Follows Isaac around shooting normal tears.

Bucket Of Lard


Gives two empty heart containers, heals by half a heart but decreases speed by 1.

Charm Of The Vampire


Killing 13 monsters heals the player for half a heart.

Chocolate Milk

Chocolate Milk Icon

Allows Isaac to charge shots, making them a lot stronger and larger, and turns them brown. Tears will no longer automatically fire while holding down arrow keys.

The Common Cold

The Common Cold Icon

Gives Isaac's shot a chance of poisoning enemies for a 2.5 seconds, and turns tears green.

The Compass

The Compass Icon

Reveals all special rooms (Boss Rooms, Treasure Rooms, Shops, etc.), but not Secret Rooms/Super Secret Rooms or regular rooms.

Cube Of Meat 40px

The first pick up gives a floating cube similar to a Pretty Fly that damages enemies and blocks shots.

The second pick up changes it into a floating head that shoots red tears and blocks shots.

The third pick up changes it into a humanoid Meat Boy, who walks around chasing enemies, but no longer shoot projectiles.
(This stage and the last stage can push bombs around, which can damage Isaac if the player is not careful)

The fourth pick up increases his size and damage.

A fifth pick up will create another cube of meat orbital which then advances to another Super Meat Boy. However, it is not possible to have three or more Meat Boys, as the ninth cube will simply disappear on pickup.


Cupid's Arrow


Gives Isaac piercing tears that can travel through enemies. Removes knockback effect of tears.

Dead Bird

Dead Bird Icon

Whenever Isaac takes damage, the bird starts attacking nearby enemies while flying over obstacles. The effect only lasts for the current room.

Dead Cat

Dead Cat Icon

Your HP is set to 1.

You are followed by a floating cat head and have 9 lives (these still count as deaths on the statistics screen).

You can increase your max HP as normal, but after each death it will reset to 1 again.


Dessert Icon

Increases available heart containers by 1.


Dinner Icon

Increases available heart containers by 1.

Distant Admiration

Distant Admiration Icon

A red attack fly circles further out than the Halo of Flies/Pretty Flies, but closer than Forever Alone.

Deals more damage than Forever Alone.

Demon Baby

Demon Baby Icon

Follows Isaac and automatically fires at enemies in its reach.

A Dollar

A Dollar Icon

Gives Isaac 99 coins.
Can be found multiple times in a single playthrough.

Dr. Fetus


Replaces Isaac's shot with a bomb.

Only one bomb can be shot at a time, and it will slide a fixed range before exploding.

Forever Alone

Forever Alone Icon

Spawns a blue attack fly that orbits a long distance from Isaac.

Growth Hormones

Growth Hormones Icon

Increase Speed and Damage by 2 each.

Guardian Angel

Guardian Angel Icon

Spawns a Guardian Angel that orbits Isaac.

Does damage on touch, blocks shots and doubles the speed of other orbitals.

The Halo

The Halo Icon

Increases all stats (Including Heart Containers) by one.

Halo Of Flies


Grants 2 Fly orbitals that circle Isaac.

Blocks shots and damages Fly enemies on touch.

The Inner Eye

The Inner Eye Icon

Gives Isaac a triple shot, sets Tears to minimum

The Ladder

The Ladder Icon

Allows Isaac to walk across gaps one square across by automatically placing a ladder between the two walkables.

Little C.H.A.D.


Isaac is followed by Little C.H.A.D, who will drop a half Heart every 2 rooms.

Little Chubby

Little Chubby Icon

Adds a small grub that follows Isaac.

Charges forward and deals touch damage to any enemies in her path. Will attack when the Isaac attacks with a moderate cooldown time before she can attack again.

Little Gish

Little Gish Icon

Follows Isaac around shooting tar projectiles that reduce enemies' movement speed, shot speed, and range for a few seconds.

Little Steve


Follows Isaac around, shooting homing projectiles.

Loki's Horns


Gives a random chance for projectiles to fire in a cross (+) pattern.

Lord Of The Pit


Isaac can fly over all obstacles, including damage floors, spikes, rocks, and pits. Increases speed by 1.

Lucky Foot

Lucky Foot Icon

All Pills picked up will have positive or neutral effects (same effect as the PHD, but without pill identification and neutral pills). Increases the chance of getting Pick Ups from clearing a room or from Poop and Fireplaces. Increases the chance of winning the Shell game in the Arcade room from 33% to roughly 50%. Increases the chances of getting items from Golden Chests.


Lunch Icon

Increases available heart containers by 1.

A Lump Of Coal


Increases damage of tears based on amount of time in the air. 0.14 damage per frame, or 4.2 damage per second.(tear size increases as it gets further away).

Magic Mushroom

Magic Mushroom Icon

Fully heals Isaac, increases all Stats (excluding Rate Of Fire) by 1, and multiplies damage by 1.5x.


Magneto Icon

Pulls Pick Ups towards Isaac.

The Mark

The Mark Icon

Increases Damage by 1, Speed by 0.2, and adds one Soul Heart.

Max's Head


Increases damage by 1, and multiplies it by 1.5x.

Mini Mushroom


Increases Speed and Range by 1.

Mom's Contacts


Gives Isaac a petrifying shot that will randomly freeze enemies solid for a few seconds.

Mom's Eye


Allows Isaac to fire tears from the back of his head.

Mom's Heels


Increases Range by 7.75.

Mom's Knife


Once collected, Isaac no longer shoots tears, he shoots a knife in boomerang style. The range of throw increases by charging the shot.

Can also be used as a melee weapon while not fired.

Mom's Lipstick


Increases Range by 7.75.

Mom's Underwear


Increases Range by 7.75.

Money = Power


Increases damage based on the number of coins the player has at the moment.

Mr. Mega


Gives Isaac 5 bombs, and makes all dropped bombs larger (Similar to the bomb dropped by Mr. Boom), which have an increased blast radius and increased damage.

My Reflection

My Reflection Icon

Gives Isaac's tears a boomerang effect, and sets range to default.

Number One

Number One Icon

Sets Isaac's tears to their maximum rate of fire and minimum range.

Odd Mushroom (Large)


Increases damage by 0.3, adds an empty Heart Container, increases range by 2.75 and reduces Speed by 0.1.

Odd Mushroom (Thin)

Odd Mushroom (Thin) Icon

Increases Speed by 1, sets Rate Of Fire to maximum while reducing Damage by 1.

Ouija Board

Ouija Board Icon

Turns Isaac's tears spectral, allowing them to go through rocks or obstacles.

The Pact The Pact Icon

Increases Damage by 0.5 and Rate Of Fire by 0.7. The player also gains 2 Soul Hearts.

The Parasite

The Parasite Icon

Makes the Isaac's tears split in two when they hit something.


Pentagram Icon

Increases Damage by 1 and increases chances of the Devil Room appearing by 20%..


PHD Icon

Changes negative Pill effects into positive ones. Also causes Blood Donation Machines to drop more money. Restores 2 hearts upon pickup.

A Quarter

A Quarter Icon

Gives you 25 pennies.

Raw Liver

Raw Liver Icon

Increases available Heart Containers by 2 and completely restores health.

The Relic

The Relic Icon

Isaac is followed by a small blue cross that will drop a Soul Heart every 5 rooms.



Follows Isaac around, shooting enemies with an eye laser similar to Technology.

Roid Rage

Roid Rage Icon

Increases Speed by 0.6. Does NOT increase range.


Rosary Icon

Adds 3 Soul Hearts and increases the chance for The Bible to appear in the Shop.

Rotten Meat

Rotten Meat Icon

Increases available heart containers by 1.

Sack Of Pennies


Isaac is followed by a small bag that drops a coin every 2 rooms.
Usually a penny, sometimes a nickel.

The Sad Onion

The Sad Onion Icon

Increases tears by 0.7.

Sister Maggy

Sister Maggy Icon

Follows Isaac around shooting blood tears.



All the various fly type enemies no longer harm you, shoot, or split.

Skeleton Key


Sets your key count to the maximum of 99.

The Small Rock


Increases damage by 1, increases tears by 0.2, decreases speed by 0.2.

Spelunker Hat

Spelunker Hat Icon

Reveals the Secret Room and Top Secret Room when passing by it and reveals if a room contains a mini-boss.

Spider's Bite


Gives Isaac's shots a chance of slowing enemies for 2.5 seconds.

Spoon Bender

Spoon Bender Icon

Gives Isaac's shots the ability to curve towards enemies.

Steam Sale

Steam Sale Icon

Reduces all Shop prices by 50%, rounded down when an item, rounded up when a pickup.



Increases Damage by 1.

Super Bandage

Super Bandage Icon

Increases HP by 1 and gives 2 soul hearts.


Technology Icon

Gives Isaac a laser shot with unlimited range.

Shots pierce enemies but not rocks, fire, or poop.

Shots can't be angled, and will not provide knockback.


Transcendence Icon

Removes Isaac's body, allowing flight over obstacles, spikes and pits.

Treasure Map

Treasure Map Icon

Reveals all rooms for every floor, including the Secret Room. However, it does not reveal icons.

The Virus

The Virus Icon

Isaac will automatically poison any enemy that he touches.

The Wafer

The Wafer Icon

Turns all types of damage into a half-heart, including damage taken in The Womb and onwards.

Whore Of Babylon

Whore Of Babylon Icon

When Isaac reaches a half-heart, he is given +2.16 damage, and his speed increases by 0.3.

Wiggle Worm


Gives Isaac waving shots and increases Rate Of Fire by 0.4.

Wire Coat Hanger

Wire Coat Hanger Icon

Increases Tears by 0.7.

Wooden Spoon

Wooden Spoon Icon

Increases speed by 0.3.

XRay Vision


Reveals and opens Secret Room entrances.

Wrath of the Lamb Passive CollectiblesModifier

The following collectible items can only be acquired if you have the Wrath of the Lamb DLC.

Objet Icône Effet

3 Dollar Bill

3 Dollar Bill Icon

Effect given changes every room.


Abel Icon

Mirrors Isaac's movements. Shoots in opposite direction to the player.


Ankh Icon

When killed, respawns in the previous room as ???, regardless of the fact he is unlocked or not.

After respawn, all future HP upgrades will be soul hearts only. Only works once.

The Black Bean

The Black Bean Icon

When taking damage, Isaac farts, causing poison damage to all enemies in range.

Bloody Lust

Bloody Lust Icon

Increases damage each time Isaac kills an enemy for the current room. (.28 damage per kill, caps at 3.3.)

Bob's Curse


Gives 5 bombs and grants all bombs poison effect.


Box Icon

Spawns 1 of each item: 1 coin, 1 key, 1 bomb, 1 heart, 1 card, 1 pill, 1 trinket.

Bum Friend

Bum Friend Icon

A portable Beggar who follows Isaac, pick up coins for himself, and occasionally drop Pick Ups. Does not spawn Collectibles. Can push around dropped bombs, similar to Meat Boy.



Increases Shot Speed by 23%.

Celtic Cross

Celtic Cross Icon

Has a 20% to create a protective shield around Isaac upon taking damage, which grants him invulnerability to all forms of damage for 7 seconds.

Chemical Peel

Chemical Peel Icon

Tears fired from left eye do increased damage.

Daddy's Love

Daddy Longlegs Icon

Daddy Long Legs' shadow follows Isaac and stomps on enemies.

Dead Dove


Gives Isaac spectral tears and flight.

Epic Fetus


Tears become guided missiles (See Doctor's Remote).


Fate Icon

Isaac gains flight and an Eternal Heart.

Ghost Baby

Ghost Baby Icon

Familiar that shoots spectral tears.

Guppy's Hair Ball


Loosely follows behind Isaac. Can be swung like a flail by rapidly spinning Isaac in a circle.

Grows bigger by killing enemies

Guppy's Tail


Increases chance of gold chests and normal chests.


Habit Icon

When Isaac is hit, 3 points of an item's charge are filled.

Harlequin Baby

Harlequin Baby Icon

Familiar that shoots a pair of tears diagonally every second while Isaac is firing.

Holy Grail

Holy Grail Icon

Adds 1 empty heart container and gives flying ability.

Holy Water

Holy Water Icon

When Isaac receives damage, the bottle breaks and a puddle of blue Creep forms, which damages non-flying enemies, similar to Lemon Mishap.

The bottle is reformed upon entering a different room.


Infestation Icon

1-3 Blue Flies randomly spawn every time Isaac gets hit.



Green projectiles fired from the mouth causing poison/explosive damage.

Jesus Juice

Jesus Juice Icon

Increases Damage by 0.5 and increases Range.

Magic 8 Ball

Magic 8 Ball Icon

Increases Shot Speed.

Drops a Tarot Card when picked up.



Adds a heart container, and increases damage.


Mitre Icon

Greatly increases the chance of replacing spawned hearts with soul hearts.

Mom's Coin Purse


Spawns 4 random Pills around Isaac.

Mom's Purse


Allows Isaac to hold 1 additional trinket.

The Mulligan

The Mulligan Icon

Chance to spawn Blue Flies on successful hits, which charge current target.

Mutant Spider

Mutant Spider Icon

Shoot four tears at once, greatly reduces tear firing rate.

Pageant Boy

Pageant Boy Icon

Spawns several coins around Isaac.

The Peeper

The Peeper Icon

Gives Isaac a familiar eye that floats around the room, damaging enemies on contact

Tears fired from left eye become red (cosmetic only)


Polyphemus Icon

Makes Isaac shoot one huge tear. Also reduces Tears to minimum. Damage increased by 4 and then multiplied by 2.

If tear does more damage than an enemy's life, the tear continues to travel with the extra remaining damage.


Pyro Icon

Adds 99 Bombs.

Rainbow Baby

Rainbow Baby Icon

Tear Effect changes every shot.

Sacred Heart


Shots are larger, travel slower and home in on enemies. Damage is multiplied. (Multiplies damage by X2.3+1, -0.4 tears, -0.25 shot speed.)

Gives 1 Soul Heart and restores full Health on Pick up.

Sacrificial Dagger

Sacrificial Dagger Icon

Dagger orbits Isaac, very high damage.


Scapular Icon

Once per room, when Isaac is reduced to his last half red Heart, the aura around his head temporarily vanishes and he is granted one Soul Heart.

SMB Super Fan!

SMB Super Fan Icon

Increases all stats except Speed by 1. Reduces Speed by 1.

Speed Ball

Speed Ball Icon

Increases movement speed and causes tears to travel faster.

Spirit Of The Night


Grants Isaac flight and spectral tears.


Squeezy Icon

+1 tears and spawns 2 soul hearts.

Stem Cells

Stem Cells Icon

Adds an extra Heart Container, heals a half heart, and increases Shot Speed.


Stigmata Icon

Boosts Isaac's damage by 0.3 and grants you one heart container.

Technology 2

Technology 2 Icon

Fires a continuous laser as you shoot tears. Decreases your damage by -35%.

Pierces enemies.


Toothpicks Icon

Increases shot speed.

Tough Love

Tough Love Icon

Isaac randomly shoots teeth instead of tears, dealing 3.2 times his normal damage.

Rebirth Passive CollectiblesModifier

Objet Icône Effet
A Snack Fichier:Rebirth a snack.png

Increases available heart containers by 1.

Anemic Fichier:Rebirth anemic.png

On receiving damage leaves trail of blood that damages enemies standing on it.

Anti-Gravity Fichier:Anti Gravity Icon.png

Tears float on the spot they were fired, and fire simultaneously when you release arrow keys.

Aries Fichier:Rebirth aries.png

Increases speed and adds contact damage.

Aquarius Aquarius Icon

Isaac leaves a trail of tears that damages non-flying enemies.

Ball of Bandages Ball of Bandages Icon

The first pick up gives a floating ball similar to a Pretty Fly that damages enemies and blocks shots.
The second pick up changes it into a floating head that shoots charm tears and blocks shots.
Further stages unconfirmed.

Best Bud Best Bud Icon

A fly orbital appears when Isaac takes damage.

Best Friends Forever Fichier:Rebirth best friends forever.png

Your Attack Flies and Spiders become stronger, and shooting familiars shoot faster

Big Fan 45px

A large, slow-moving orbital that blocks shots and damages enemies.

Blood Clot Fichier:Rebirth blood clot.png

Increases Damage and Range for tears fired from left eye.

Bob's Brain Fichier:Rebirth bobs brain.png

A familiar that launches at enemies and explodes when it hits an enemy.

Caffeine Pill Fichier:Rebirth caffeine pill.png

Increases speed, decreases size and gives yellow pill.

Capricorn Fichier:Rebirth capricorn.png

Increases all stats.

Dark Matter Fichier:Rebirth dark matter.png

Turns your tears black. They will occasionally cause fear on hit, which turns the enemy purple, gives it a purple skull over its heads, and causes it to run from you without attacking for 5 seconds.

Gimpy Fichier:Rebirth gimpy.png

Isaac has a chance to drop a Soul Heart whenever he receives damage.

Gnawed Leaf Fichier:Rebirth gnawed leaf.png

Isaac turns into an invulnerable statue when standing still.

Goat Head Fichier:Rebirth goat head.png

Increases chance to find a Devil Room.

Guppy's Collar Fichier:Rebirth guppys collar.png

50% chance to get additional life after death.

Headless Baby Fichier:Rebirth headless baby.png

A familiar that follows Isaac and leaves trails of red Creep.

Holy Mantle Fichier:Rebirth holy mantle.png

Nullifies damage once per room.

Infamy Fichier:Rebirth infamy.png

Blocks half heart damage from direction Isaac is facing.

Infestation 2


Infestation shot. Sometimes spawns friendly spiders in place where enemy die.

Latch Key Fichier:Rebirth latch key.png

Increases Luck and gives 2 keys.

Leech Fichier:Rebirth leech.png

A familiar that follows enemies, dealing contact damage and restoring Isaac's health.

Libra Fichier:Rebirth libra.png

Gives you 6 coins, 6 bombs and 6 keys, and balances stats.

Lil' Brimstone Fichier:Rebirth lil brimstone.png

A familiar that shoots Brimstone beams.

Lost Contact Fichier:Lost Contact.png

Your tears can destroy enemy projectiles.

Mysterious Luquid


Toxic splash damage.

Match Book

Image required

Spawns 3 bombs and gives 1 evil heart.

Magic Scab Fichier:Rebirth magic scab.png

HP and luck up.



Tears up and knock-back shot.

Placenta Fichier:Rebirth placenta.png

Increases max health by 1, and adds red heart regeneration.

Rotten Baby Fichier:Rebirth rotten baby.png

Companion that shoots attack flies.

Scorpio Fichier:Rebirth scorpion.png

Gives poison tears.

Screw Fichier:Rebirth screw.png

Increases tears and shot speed by 1.

Sissy Longlegs Fichier:Rebirth sissy longlegs.png

Companion that spawns attack spiders.

Spider Baby Fichier:Rebirth spider baby.png

Spawns spider Familiars when Isaac receives damage.

Tiny Planet Tiny Planet Icon

Increases range and makes tears orbit Isaac.

Trinity Shield Fichier:Rebirth trinity shield.png

Protects Isaac from ranged attacks in the direction he is facing.

Virgo Fichier:Rebirth virgo.png

Chance to gain temporary invincibility whenever you are damaged.


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