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Items are an integral part of gameplay in The Binding of Isaac. They modify a character's stats, grant or modify abilities, among many other things. There are 198 different items in the game. Below is a list of all of the items, separated into categories. Certain items change the appearance of your character when they are acquired. Items you've found can be seen in the Collection page.

Caution - Please remember that the game saves on a timer, and also saves when you use the in-game exit command. It is possible to lose unlocked items, bosses, statistics and so on if the program is improperly closed without a chance to save.

Note: Please keep discussion of what items are better than what out of the tables. Use the Item Discussion page for that.

Item DemonstrationsModifier

Videos of items in use can be found by clicking on the Fichier:Movie strip.png link in the info section for that particular item. Note that these are external links and will navigate away from the wiki.

Acquiring ItemsModifier

The main ways of obtaining items are by entering Treasure Rooms and defeating Bosses. Items can also be purchased from Shops, found from Beggars, obtained by making deals with the devil, found in a Secret Room, dropped by standard enemies, and collected through other, less evident means, such as blowing up a Tinted Rock or opening a golden chest. It is possible to acquire activated/collectible items in the Challenge and "I AM ERROR" rooms. There are also five specific items you can get in the Arcade: Skatole from the Shell Game, either the blood bag or the IV Bag from the Blood Donation Machine, and either the Dollar from the Slot Machine or Crystal Ball from the Fortune Teller Machine, whichever happens to be in the Arcade.

Note 2: It is possible to "pick up" an item you didn't intend in the Boss Room with the trapdoor. If you have a high speed and walk into the trapdoor in the direction of the item, you will show as dropping into the trapdoor but your familiars will fly on ahead as if you were still moving. If they come near the item, it's possible it may get picked up.

Note 3: All characters (except for Isaac, until the The Dice is unlocked) will start out with items.

Activated ItemsModifier

Main article: Activated Items

These items are stored in the Spacebar slot and are used up once the button is pressed. The items then recharge in one of two ways. Normally, they charge a number of bars after every room you clear, some items charge one bar at a time, others charge faster. Note that only rooms where the doors close until they are cleared count, bosses, arenas, enemy rooms, etc. The Collectible Item "Battery" can give bars of charge during combat, on top of the normal recharge. Another Collectible Item, the "9 Volt" will automatically recharge 2 bars when an item is used; this effectively reduces the number of rooms required to charge an item if the item requires 3 or more rooms to charge. In the Wrath of the Lamb expansion, there is another item, the Habit, which will recharge bars when taking damage. To see a clearer version of the in-game arrangement. go to the Collection page.

Note: You can only hold one of these at a time.

Additional Note: Any two of the same activated item on the same floor will share charge state, i.e. finding another of the same activated item' when one is not fully charged' will not give the player another fully charged version of the item.

Item Effect Info Rooms to Recharge Collection Grid


Anarchist Cookbook

Anarchist Cookbook Icon

Spawns six troll bombs around the room.

Frequently dropped by Pride.

The XIV Tower tarot card has the same effect.



The Bean

The Bean Icon

Causes Isaac to have bad gas, damaging and poisoning any enemy in close vicinity.

(Same as the Bad Gas pill)

Unlocked by destroying 50 poop piles.




Bob's Rotten Head

Bobs Rotten Head Icon

Throws a bomb in the direction Isaac's facing. It does extreme damage, poisons the enemy for five seconds, and destroys rocks. Bombs will arc back towards Isaac with the My Reflection upgrade.

Isaac can be damaged by the explosion if he is within the blast radius (though he cannot be poisoned).


Having Brimstone and attempting to use Bob's Rotten Head causes you to get stuck.

Dealing poison damage to War while off screen causes him to get stuck in the walls.

Having Technology 2 renders you unable to throw Bob's Rotten Head.

Sloth and Pestilence are highly resistant to the blast and immune to the poison. Appears in Secret Rooms or as a drop from Sloth.



The Bible

The Bible Icon

Transforms Isaac into an angel, allowing him or her to fly over obstacles for the current room only.

Instantly kills Mom, Mom's Heart, and It Lives.

Satan or Isaac will instantly kill you for using it, even after death (unless you have The Wafer).



The Book Of Belial

The Book Of Belial Icon

Doubles damage until you exit the room, just like XV The Devil tarot card. It also gives Isaac an angry face with empty eye sockets with blood running down his face until he exits the room.

Fichier:Bookofbelial Isaac.png

Unlocked by beating the full game. Can rarely be found in Secret Rooms and the Devil Room, as well as in the Library. Judas starts the game with this item.

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Book Of Revelations

Book Of Revelations Icon

Adds one Soul Heart.

Using the book will ensure you meet a Harbinger as the level boss, if possible.

May also cause you to fight the Headless Horseman in Sheol instead of the final battle with Satan.

This item is most commonly found in Shops, but it can also be found in the Library, Devil Room or even in the Item Room. It's also a rare drop by the Beggar.

Unlocked by killing any Harbinger



Book Of Shadows

Book Of Shadows Icon

Grants invulnerability for 12 seconds. Will start flickering before stopping.

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This cannot be used to get items from the Devil Room without paying.

You can farm Blood Donation Machines and Devil Beggars for free while this item is activated.

This item can be found in the Library, the Item Room and the Shop.

Trivia: This book is a reference to the book used by the witch sisters in the TV series "Charmed".

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The Book Of Sin

The Book Of Sin Icon

Spawns a random pick-up, pill or tarot card.

Unlocked by beating each of the Seven Deadly Sins.

Can be obtained in the Devil Room or found in the Item Room.



Dead Sea Scrolls

Dead Sea Scrolls Icon

Uses a random Activated Item (even locked ones)

If the item mimicked has no recharge time (Kamikaze! for example), the scrolls can be used again immediately with no recharge period.

Beware, this item may harm the player if the effect mimicked can do so.

Sometimes causes Globins to "moonwalk" when used.

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Deck of Cards

Deck Of Cards Icon

Gives Isaac a random tarot card.

The card spawns in the player's inventory. This will cause the player to drop the currently held Q slot item when used.



The Dice

The Dice Icon

Re-roll all activated and collectable items on screen.

It can also be used to change Shop items or boss drops. The exception is with special drops from alternative bosses, like Cube of Meat from the Horsemen or Little C.H.A.D. from C.H.A.D., which will simply replace them with the same item.

The Dice re-rolls items from the same pool, eg. a Secret Room reroll will only yield another Secret Room item.

It is possible to obtain items only unlockable through achievements using The Dice without having completed the achievement.


It is possible to exploit this nature to obtain two Cubes of Meat from one Horseman. Using The Dice while a Cube of Meat is onscreen can change other items, such as a Small Rock or an item from a Beggar spawned with the XX Judgement tarot card, to turn into 'Cubes of Meat (for example, here are 3 cubes on one screen).

There is a small chance that the new item will be undefined. See the bugs section for more information.

Unlocked by completing The Womb with ???.

After being unlocked, Isaac starts the game with this item.

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Doctor's Remote

Doctors Remote Icon

Sets a big red target on the ground which can be controlled with the arrow keys or mouse clicks. After several seconds, a huge explosive missile hits it.

Pressing space at any time during the targeting phase will launch the missile at the target.

Trivia: This item is a reference to an item used by Dr. Fetus from "Super Meat Boy".

The missile acts like a huge bomb explosion.

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Forget Me Now

Forget Me Now Icon

When activated, the level ends and is freshly regenerated with new rooms, monsters, and items. Disappears after use.

Using this effectively forces you to abandon your current Activated Item.

This item is a reference to "Arrested Development", where the character Gob calls roofies "Forget Me Now".

Unlocked by completing Sheol with ???.

One-Time use


The Gamekid

The Gamekid Icon

Isaac turns into a Pac-Man like creature, gaining invincibility, the ability to damage enemies on touch, and causes enemies to run away for five seconds. Heals one-half heart for every two enemies killed while in use.

Health leech will not work on bosses unless delivering the killing blow, it will however work on monsters spawned by bosses, granting Soul Hearts instead.

The health leech also does not work with ???.

There is a bug when using the Gamekid with Technology. The controls will be inverted for the left and right fire until you leave the room. It will also sometimes visibly move your head until you leave the room. (Probably in combination with Technology, but not confirmed.)


Does not work on the Masks of Evil enemy, even while chomping the hearts.

When used in the Devil Room, the heart colors appear darker, but these are NOT turned to Soul Hearts (buying an item will cost normal hearts).

You can farm Blood Donation Machines with this item. When used, the Blood Donation Machines will turn blue.

This item icon is a reference to the Nintendo Gameboy, one of the first portable gaming systems, and the transformation is a reference to Pac-Man.

Unlocked by visiting arcades 10 times.

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The Hourglass

The Hourglass Icon

Slows enemies and enemy projectiles for 7.5 seconds.


When this item is used on bosses that fire exploding arced shots (Sloth, Pestilence, etc.), twice the normal amount of the shots are fired.

If used while The Fallen copies himself, The Fallen becomes four, instead of two

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Kamikaze Icon

Causes an explosion in the same area as Isaac, causing one heart of damage, but also damaging monsters caught in the blast.


Unlike Blood Donation Machines, this will use up your Soul Hearts as well. Affected by The Wafer's damage resistance.

Can be used multiple times without losing any hearts while under the invincibility effect of the VII The Chariot tarot card.

This does not count towards "take no damage" achievements.

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Lemon Mishap

Fichier:Lemon Mishap Icon.png

Causes Isaac to have an accident, creating a pool which damages anything that crosses it (except for the player).

Flying enemies are not damaged by the pool.

Similar to Peep's ability.

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Mom's Bottle of Pills

Fichier:Moms Bottle Of Pills Icon.png

Spawns a random pill near Isaac.

A player will only receive six different pill types in one playthrough.

The pill spawns in the player's inventory. This will cause the player to drop the currently held Q slot item when used.

Unlocked by using a Blood Donation Machine 20 times.

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Mom's Bra

Fichier:Moms Bra Icon.png

Causes Isaac to wear the bra for a short period of time and freezes enemies for the next five seconds.

If used on Mr. Maw, the head part of it will re-appear after the freeze effect ends.


If this item is used on Satan, it may cause a bug that makes winning impossible. See the bugs section.

If used on Fistula, this can cause divisions of the boss to get stuck on rocks.



Mom's Pad

Fichier:Moms Pad Icon.png

Causes enemies to back away from Isaac for five seconds.


If used against stationary bosses like Gurdy, they will slide away, but recenter after its duration ends.

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Monster Manuel

Fichier:Monster Manuel Icon.png

Summons a random familiar (even locked ones) for the current room only.

Trivia: This item's name and graphic are both references to the D&D Monster Manual.

Summoning "A Cube of Meat" will summon a random level of Meat Boy (one through four).

Unlocked by completing Sheol with Judas.



Monstro's Tooth

Fichier:Monstros Tooth Icon.png

Monstro jumps onto a random enemy, doing damage.

Monstro can do damage to you if he lands on you or you walk into him. This cannot be used against Monstro.

Monstro can be damaged when he appears on screen and can be killed if you freeze him or he gets caught in Satan's laser attack, but drops nothing on death.


Despite the fact that it can't be used on Monstro, it can be used on Monstro II.


If used on War when he jumps up to drop Troll Bombs, he will become stuck and the player will be unable to do anything.

Unlocked by beating all bosses in The Basement.



Mr. Boom

Fichier:Mr Boom Icon.png

Drops a large bomb.

It has an increased blast radius of three squares in contrast with the two squares of regular bombs.

Does not destroy doors like normal bombs.



My Little Unicorn

My Little Unicorn Icon

Grants Isaac temporary invincibility while damaging enemies by touch.

Trivia: This item's name is a reference to "My Little Pony", a popular television show featuring unicorns and magic. Isaac won't fire unless he's holding Mom's Knife. Familiars will attack as normal.


You will still lose coins from touching Super Greed while this item is activated.

You can farm Blood Donation Machines for free while this item is activated.

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The Nail

The Nail Icon

Turns Isaac's body black with twisted horns, adds one Soul Heart and allows the breaking of rocks by simply walking over them. Also crushes frozen enemies when walking through them. Increases damage by one and decreases speed by one. Also allows the breaking down of the Challenge Room door.

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Unlocked by completing game three times. Available in the Devil Room (or as a possible drop from The Fallen). Also appears in the Curse Room and can be given by the Devil Beggar if you have the Wrath of the Lamb expansion.



The Necronomicon

The Necronomicon Icon

Damages all enemies in the room significantly.

Unlocked by using the XIII Death tarot card four times.

It will also destroy all enemy shots on the screen at the time you use it.

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A Pony

A Pony Icon

While equipped, increases speed by two and allows Isaac to fly over rocks, pits, blood, and spikes.

Upon use Isaac will charge in the direction selected and deals damage to monsters.

This is a possible reward from defeating the Headless Horseman (the other being the Cube of Meat).

The Pony is the only spacebar item with a passive effect while it is equipped. If it is replaced by another item, these bonuses are lost.

If spacebar is pressed but directional buttons are not, your character will become permanently invincible and will deal damage to all enemies that touch.

Can be used to touch the Blood Donation Machine without taking damage.



The Poop

The Poop Icon

Drops a pile of poop, exactly like the ones that litter the basement.

Will block enemies' movement and attacks.

As with regular poop, destroying it may yield coins or hearts.

Unlocked after 10th playthrough.

??? starts the game with this item.

A strategy for this item is to use it to block out enemies shots, since it will act as a shield.

When used while being on a spider web, poop does not appear.




Razor Blade

Razor Blade Icon

Deals a certain amount of damage to self, in exchange for increased damage in the current room.

Eve before and after using the Razor Blade

.Fichier:Eve Razor Blade small.png

As with the Blood Donation Machine, this uses up your Heart Containers first before it takes your Soul Hearts.

Unlocked by completing The Womb by Eve.


Will cause death if it removes the last whole remaining Heart Container, even if Soul Hearts remain.

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The Pinking Shears

Fichier:The Pinking Shears Icon.png

Separates Isaac's head and body for a single room. Control is retained for his flying head while his decapitated body will automatically attack enemies in range dealing high damage (essentially a powered-upMeat Boy).

Unlocked by dying 100 times.

Found in Shops and the Item Room. Also spawned by The Dead Sea Scrolls.

When used in conjunction with Habit, it is possible to have multiple copies of Isaac's body all attacking enemies.

(If you are using an item that makes Isaac Black, such as Lord of the Pit, the body will also be Black.)



Shoop Da Whoop!

Shoop Da Whoop Icon

Fires a laser from Isaac's mouth. Using the item charges the laser, it can then be fired in the chosen direction. The laser penetrates all obstacles and enemies in its path and can damage multiple enemies.

Fichier:Shoopdawhoop Isaac.png

Trivia: This item is a reference to an internet meme of the same name originating from 4chan, depicting a face similar to the icon firing a lazer.

This item can sometimes be dropped by Envy.

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Tammy's Head

Fichier:Tammys Head Icon.png

Shoots 10 projectiles in a circle around you.

Modifiers to your primary fire also modify the tears used for Tammy's Head as well (eg. Boomerang Shot, Homing Shot).

Charges after every room.

Tears do not turn into Brimstone lasers, Technology lasers, or Dr. Fetus bombs and will behave as any tears Isaac would fire should he not have any of the items mentioned.

More commonly found in Chests than anywhere else.


Tears fired by Tammy's Head do highly incresed/max damage.




Teleport Icon

Teleports the player to a random room, including Secret Rooms and the Boss Room.

Can teleport to the I AM ERROR room, otherwise only accessible via Teleport or the consumption of Telepills. Chance of this happening varies between 5% and 10% per teleport, chance lowers as floors increase in number of rooms.

If Isaac teleports into the Devil Room before beating the boss, he will leave to the first room on the level. This potentially allows to skip Mom's Heart entirely.

Can also be used (along with other player moving items) to reset champion bosses for a different version by use during the boss fight.

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We Need To Go Deeper

We Need To Go Deeper Icon

Creates a trap door to go to the next level.

Using on Womb 2 creates a trap door to Sheol (even if Sheol has not been unlocked yet). Will not have an effect in Sheol.

Does not count for certain achievements that require going through an area without getting hurt if used in the second part of a level (Basement 2, Cave 2, Depth 2 and Wombs 2) because the second boss must be killed to unlock said achievement. Nevertheless, for these achievements, this item can be used in the first part of a level (Basement 1, Cave 1, Depth 1 and Wombs 1).

This item appears in Secret Rooms or the Devil Room, and is a possible drop from The Fallen.

Cannot be used to skip from Cathedral to the Chest, even if you have the Polaroid.



Yum Heart

Yum Heart Icon

Restores one whole heart.

Unlocked by having seven Heart Containers.

Useless with "???"

Magdalene starts the game with this item.

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Wrath of the Lamb Activated ItemsModifier

The following activated items can only be acquired in the Wrath of the Lamb expansion.

Item Effect Info Rooms to Recharge Collection Grid


Best Friend

Best Friend Icon

Deploys a decoy Isaac that eventually explodes.

The explosion can hurt Isaac if they are within the blast radius.

High chance of getting eaten by Chub like regular bombs.

Orbiting items such as meat cube and sacrificial dagger will be transferred to the doll when activated.

If you have Distant Admiration, Forever Alone, or other type of follower fly when you use this item the flies will follow the decoy until it explodes.


If you activate Best Friend while you have the Sister Maggy familiar, Sister Maggy will turn into Ghost Baby until the decoy explodes, after which it will revert back to Sister Maggy immediately.

After activated, if the doll is hit by The Fallen's cross blood beam, it will count as you died. May occur with other attacks.
3 (B,6,3)

Blood Rights

Blood Rights Icon

Consumes health to damage all enemies in the room.

Unlocked by defeating Satan as Samson.

Makes blood pour from the walls.

Like Necronomicon, destroys Masks of Evil without killing their hearts.

0 (B,6,8)

The Candle

The Candle Icon

Throws out a blue flame that can pass over gaps (but not through rocks) that damages anything in its path.

Recharges itself.

Unlocked by completing Challenge 1.

Recharges in about three seconds, even faster with The Battery.

The flames can damage Mom when fired at any of the four doors in the room, even when they are closed and It Lives when it is hidden from view, simply by firing into the centre of the room.

The flames can damage Satan's second form when used on the statue present when fighting his first form (The Fallen). The statue will flash red upon taking damage and Satan's second form will start with health missing.

Evaporates enemy shots.

Possible reference to the "Candle" item from "The Legend of Zelda" series.

It will often be available for purchase in the store.


If the player has Mom's Knife and The Candle, it is possible launch the knife an infinite range by pressing the fire key, moving in the same direction and pressing Space to use the candle. The knife will move at the speed you did before you hit space. The Knife still will deal damage and is possible to expliot this to candle knife bosses for massive damage.

Fichier:Binding of isaac-Mom's knife The Candle bug 1.4.3
0 (B,4,6)

Crack The Sky

Crack The Sky Icon

Calls heavenly beams of light to fall upon your enemies dealing mass damage to whatever they hit.

Random attack pattern.

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4 (B,10,5)

Crystal Ball

Crystal Ball Icon

Reveals the map and grants a random tarot card or Soul Heart.

Found from a fortune telling machine.

It is possible to already have a Crystal Ball while finding another one in a fortune telling machine. In this case, the charge levels of both balls will be the same.

6 (B,8,5)


Fichier:D 20.png

Randomly changes all Pickups in the room.

This includes undetonated troll bombs, trinkets, and chests, even empty ones that would despawn after leaving the room. This includes the Troll Bombs dropped by War and Pride.

Unlocked by completing the Cathedral as Isaac.

Found in the Item Room.

Does NOT reroll Item Room items, Challenge Room items, Shop items, or Devil Room & Angel Room items.


6 (B,6,6)

Dad's Key

Dads Key Icon

Unlocks all normal doors in room when used. Allows the player to exit a fight.

Can unlock Devil's Room during a Boss Fight.

Can be used to escape a Challenge Room

Unlocked by beating the boss in The Chest.

Found in the Secret Room and the Item Room.

2 (B,5,7)

Guppy's Head

Fichier:Guppys Head Icon.png

Spawns two to four Blue Flies to damage enemies. Flies won't spawn if entering a door while using it.

Found in Devil Room for two Heart Containers, Red Chests, Challenge Room or as a drop from fight with The Fallen.

If you collect any three of the Guppy's items (Guppy's Head, Guppy's Tail, Guppy's Paw, Dead Cat), Isaac will becomes Guppy. If it's Guppy's Paw or Guppy's Head, you only need to use it once (you can drop it afterward) to make the game count you as "carrying" the item.

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1 (B,5,4)

Guppy's Paw

Fichier:Guppys Paw Icon.png

Removes one Heart Container in exchange for gaining three Soul Hearts.

Useless for ???.

Found in Curse Rooms, Devil Rooms and from bosses.

Can be used again instantly after use providing there is at least one Heart Container left.

If the player uses a XI Strength tarot card, they may exchange the temporary Heart Container for three Soul Hearts.

One of the four items that will turn you into Guppy if you collect any three of them. Check Guppy's Head for the details.



IV Bag

Fichier:IV Bag Icon.png

Exchanges hearts for coins.

Can be activated during post damage invulnerability for free coins. If timed properly, it can be activated three times in a row while under post damage invulnerability to generate coins for the cost of one activation.

Works well with Bloody Penny.

Portable Blood Donation Machine.

Reward from Blood Donation Machine.

The health cost of using IV Bag is equal to the health cost of the Blood Donation Machine it came from.

If the Book of Shadows is activated before picking up the IV bag, you can spam the IV bag for about 20-30 coins before the shield wears off.

When used, if immediately used afterwards, you can get another use of the IV bag for the cost of a half-heart.

0 (B,5,3)

Notched Axe

Notched Axe Icon

Breaks a single rock when activated. Can also be activated again to put away the pickaxe if you haven't used it.

Will destroy rocks, poop and extinguish fires.

Found in the Item Room and in the Shop.

Reference to Minecraft creator Markus "Notch" Persson, as well as the Minecraft item "Iron Pickaxe".

1 (B,7,4)

Prayer Card

Prayer Card Icon

Grants half an Eternal Heart per use.

Completing an Eternal Heart (i.e. getting two halves) or having half an Eternal Heart when you progress to the next floor will convert it to a full Heart Container.

Works well with ???.

Found in the Item Room, Shop and Angel Room.
6 (B,6,4)

Portable Slot

Fichier:Portable Slot Icon.png

Same effect as the Slot Machine.

Costs one coin to use.

Found in the Item Room, Shop and Golden Chests. Can also be dropped by the Devil Beggar and Beggar.

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Remote Detonator

Remote Detonator Icon

Bombs you place explode only when you use this item.

Gives fives bombs.

Also destroys T.N.T. on use.

Dr. Fetus bombs will detonate on their own but can also be detonated earlier. Also works on Wrath's bombs.

Has no cooldown.

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0 (B,7,3)

Spider Butt

Spider Butt Icon

Damages all enemies in the room and inflicts slowdown condition like Spider's Bite.

Found in the Item Room.

Unlocked by completing Challenge 8.

2 (B,1,7)

Telepathy For Dummies

Fichier:Telepathy For Dummies Icon.png

Tears track targets for one room. Same effect as Spoon Bender.

Found in the Library Room and Item Room.

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2 (B,2,9)

White Pony

Fichier:White Pony Icon.png

Increases speed by two and allows Isaac to fly while equipped.

Upon use Isaac will charge in the direction selected and deals damage to monsters. In addition, when used it also has the Crack the Sky effect.

While carrying this item, may cause the Headless Horseman to ride a White Pony.

One of Conquest's drops, aside from Cube of Meat.

6 (B,1,8)

Collectible ItemsModifier

These items generally give you some kind of a boost to your stats, or add a special passive ability. They take effect immediately once picked up, and continue for the rest of the game (except for several items that do not provide any lasting effect).

Edmund McMillen split them up in his blog into the subcategories weapon item, stat padding items, passive items, and familiars.

Name and Icon Effect Info Collection Grid (Pg,X,-Y)


Fichier:Less Than Three Icon.png

Increases available Heart Containers by one and restores all health.

Trivia: This item beats in a similar way as the heart seen in the title screen of Spewer, another game from Edmund McMillen.

This item is sometimes dropped by Gluttony and can be found in Item Rooms.

Fichier:Heart Isaac.png

Attaches a beating heart to Isaac's chin.


Fichier:1 UP Icon.png

Gives Isaac an extra life in that upon death, Isaac will respawn in the previous room with full health.

Stacks with Guppy (Dead Cat). Has priority over Guppy if the player has accquired a health increasing collectible since obtaining Guppy.

Can be picked up multiple times in one playthrough.


Sister Maggy or Little Steve will turn into Brother Bobby until exiting the room.

Having a 1UP while doing a deadly trade with the devil, or dying at any other time when you have no normal Heart Containers, results in a rebirth with zero Heart Containers, unless Guppy was bought before.

Dying as you defeat a boss can provide you with both the item you earned and an opportunity to fight the boss a second time, earning a second item.

Only appears in Secret Rooms.


Familiar: Follows the player.

Is a reference to the "Super Mario Bros." series.


9 Volt

9 Volt Icon

Leaves Isaac with two bars already charged after using an item.

Upon pickup, Isaac's current activated item will be fully charged.

This item is most common in Shops.

Fichier:Nine Volt Isaac.jpg

Makes a battery appear smashed into Isaac's head.

The Battery

The Battery Icon

Gives Isaac an extra charge every 15 seconds per room, up to a maximum of three charges. Using an item will reset the counter and let the player charge a maximum of six bars per room.

If used in conjunction with X-ray Vision  / Dr Fetus , this allows an infinite use of the activated item by running between uncompleted rooms and the secret room / blowing up the a door of an uncompleted room, running out and in again. Using The Book of Revelations or The Nail for example can provide unlimited Soul Hearts.

This item is most common in Shops and can be dropped by beggars.

Fichier:Battery Isaac.jpg

Makes Isaac have Frankenstein bolts on his neck.

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The Belt

The Belt Icon

Increases Speed by two.

Boss Room drop or in the Item Room.

Fichier:The belt.jpg

Gives Isaac a belt.

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Blood Bag

Fichier:Blood Bag Icon.png

Increases available Heart Containers by one, Speed by one and restores four hearts.

Can be won and picked up multiple times during one playthrough.

The Blood Bag and A Dollar rewards can be "re-rolled" with The Dice.

Final reward from Blood Donation Machine.

Fichier:Blood Bag Isaac.jpg

Makes Isaac have a blood stained face, and sharp teeth.


Blood Of The Martyr

Fichier:Blood Of The Martyr Icon.png

Increases Damage by two, turns Isaac's tears into blood tears.

Found in the Item Room, Angel Room or Curse Room.

Fichier:Blood of the martyr.jpg

Isaac gains a crown of thorns.


Bobby-Bomb Fichier:Bobby-Bomb Icon.png

Gives five bombs and causes all bombs to slowly slide towards the closest enemy.

If the player has the Dr. Fetus powerup (converting tears to bombs) then it also applies to those.

Bobby-Bomb affects Wrath's bombs as well, causing them to move toward Wrath.

No visual effect.

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Bomb Bag

Bomb Bag Icon

Isaac is followed by a small bag that drops a Bomb, 1+1 Free, or Troll Bomb upon completion of every three rooms.

Unlocked by completing Sheol with Cain.


Familiar: Follows the player.

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Gives 10 bombs.

Found in the Item Room or Challenge Rooms.

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Adds a lit fuse to Isaac's head.


Breakfast Icon

Increases max health by one Heart Container.

Boss Room drop and can be dropped by the Beggar.

No visual effect. (A,7,3)


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Changes tears to a chargable laser that pierces all objects in its path be they rocks, poop or Knights. It can only be fired after a short charge-up period (approximately two seconds or until Isaac's head flashes red). The laser is channeled for about two seconds so it is possible to destroy some two-stage enemies in one shot (Globins and Hives along with the flies they spawn on death), or to strafe the shot over multiple enemies.

It is possible to charge before entering a room so that the first shot can be fired immediately. (for half its damage)


Another shot can be charged during the attack animation of the first. To attack at maximum speed, release to attack and then instantly start holding again to fire about a second after the first blast is done. As of v1.48, this appears to have been changed. If you begin charging Brimstone while firing, the shot will be cancelled.

Increasing Isaac's Tears stat reduces charge up time of Brimstone.

Increasing Isaac's damage stat does increase Brimstone's damage.

Removes knockback effect of tears.

If you obtain Brimstone after getting the Dead Dove, Isaac will take the form of Lord of the Pit but shoot the Brimstone laser

(Other synergies available on the Item Synergy page.)

Brimstone's charge (open mouthed laser) will overlap any item that is on the player's face, this is obviously a graphical bug.

As of 1.3, attempting to recharge the laser while it is firing will stop the laser, preventing it from firing or causing it to do less damage.

Available in Devil Room for one or two hearts or as a reward after fighting The Fallen. Also may be given as a gift from the Devil Beggar.

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Isaac appears demonic.


Brother Bobby

Brother Bobby Icon

Follows Isaac around shooting normal tears.

Found in the Item Room or in the Devil Room. Can also be a reward from the Devil Beggar and The Fallen

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Familiar: Follows the player.

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Bucket Of Lard

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Gives two empty Heart Containers, heals by half a heart but decreases speed by one.

This item is rarely dropped by Gluttony. Can also be found in Item Rooms.


Isaac appears significantly fatter than usual.

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Charm Of The Vampire

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Killing 13 monsters heals the player for a half-heartt.

This can be used to the player's advantage when fighting Globins. Every time they get to the pulp form, it counts as a kill. Therefore, if Charm of the Vampire is present, one could get several hearts by shooting at Globins but not completely killing them, and when they revive, repeating the process.

Splitting apart Envy, Fistula, and The Fallen will count as one kill. Killing Flies does not increase the counter.

If the kill counter reaches 13 while at full hearts, the counter resets and the heal is wasted.

Useless to ???.

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Issac gains a smirk and sports a widow's peak similar to that of the original Dracula, as well as vampiric fangs and blood dripping out of his mouth.

Chocolate Milk

Chocolate Milk Icon

Allows Isaac to charge shots making them a lot stronger and larger, and turns them brown.

Increases firing speed of Spoon Bender, and amplifies The Inner Eye after a slightly longer charge. (Other synergies available on the Item Synergy page.)

A good combination with Chocolate Milk is an auxiliary shooting familiar like Little Steve or Brother Bobby. This is because while you are charging up your shots, your auxiliary familiar will continue shooting. This can buy you time so you can fully charge up.

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Cheeks inflate while shots are charged.

The Common Cold

The Common Cold Icon

Gives Isaac's shot a chance of poisoning enemies for 2.5 seconds and turns tears green.

Unlocked by collecting two of either Roid Rage, The Virus, or Growth Hormones in one session.


When Hosts are poisoned, they will take damage only when they rise up to shoot.

Knights can be poisoned from the front.


If you shoot at bombs they will turn green, and the explosion will also be green but the effect of the bomb stays the same.

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Isaac gets sick. Instead of crying, Isaac will now spit green projectiles that have a chance to poison the enemy upon impact.



The Compass

The Compass Icon

Shows the icons of special rooms (Item Room, Boss Room, the Shop Room, the Arcade Room, Mini-boss Room) on the map without revealing rooms.

Does not reveal secret rooms. This will reveal if Greed is present by displaying a mini-boss icon with the shop icon.

Common in Shops and occasionally found in Challenge Rooms. Available from the Beggar. Never found in Item Rooms.

No visual effect. (A,3,3)

Cube Of Meat

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This item can stack and has different effects based on how many cubes have been collected.


The first pick up gives a floating cube similar to the Pretty Fly that damages enemies it touches and blocks projectiles.


The second pick up changes it into a floating head that still damages on touch and blocks projectiles, but now also spits blood shots.


The third pick up changes it into a humanoid Meat Boy, who walks around chasing enemies, but no longer shoots projectiles. On occasion, it will unintentionally shove items aside while following you or attacking enemies, including bombs.


The fourth pick up increases his size and damage. (He still shoves items.)

Collecting a fifth Cube of Meat will provide another floating cube (so in theory after collecting an eighth Cube of Meat, the player would have two level four Meat Boys. The bug where a fifth cube would create a "headless boy" instead was fixed, as seen in this video.)


If you have more than two Pretty Flies, the Cube of Meat will circle Isaac where the third fly should be, though the fly will still be visible.


On the second pick up when entering a room, it will turn into brother bobby for a split second.

Unlocked by completing The Depths.

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Level one to two:

Orbits around Isaac. At level two, it shoots blood.

Level three to four:

Follows the player (familiar)


Cupid's Arrow

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Gives Isaac piercing shots that will travel through and damage multiple enemies and cause damage to Knights from the front. Shots don't go through obstacles.

Removes knockback effect of tears.

If you have Parasite and Cupid's Arrow, tears will no longer split when they hit enemies.

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Isaac wears a Native-American head-dress.


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Dead Bird

Dead Bird Icon

Whenever Isaac takes damage, the bird starts attacking nearby enemies while flying over obstacles. The effect only lasts for the current room.

This item can be activated through self-damage.

Eve starts the game with this item.

Sprite is from an earlier game titled "AVGM", which is another game by Edward McMillen.


This item can be exploited to defeat bosses more easily because you only need to get hit by the boss once and the Dead Bird will attack the boss, thus being a big help.

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Isaac: A small bird trinket is on Isaac's head.

Follows the player after activation (familiar)

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Dead Cat

Dead Cat Icon

Found in the Devil Room, Curse Room, and random Red Chests found in Challenge Rooms and room loot.

Isaac's max health is set to one Heart Container. You are followed by a floating cat head and have nine lives (these still count as deaths on the statistics screen). You can increase your max health as normal, but after each death it will reset to one Heart Container again. (one Soul Heart with ???)

Even if you have more than three Heart Containers, you will only have one Heart Container left once you purchase Guppy, since it sets your max health to one Heart Container immediately, not after your first death. If you buy him for the price of two Heart Containers from the devil and you have two or fewer Heart Containers, you will acquire him, die, and respawn with one Heart Container (therefore losing one of the extra lives. ???'s health will be set to Soul Hearts. If you have no health at all, you will get one Heart Container that is filled half). The cost of purchasing items in the Devil Room must be met, but if it would kill you, you will respawn.


After defeating a boss, if you die after the item appears but before the boss disappears you will be able to fight the boss a second time for yet another item. (Pick up the item, then kill yourself with a bomb or something similar. You will then respawn outside the Boss Room with one less life on your counter. Going back inside the Boss Room allows you to now fight the boss again for another item. Can be done as long as you have additional lives on your counter. Can also be performed after picking up a 1UP.)

Guppy will sometimes appear as a collectable item as well as in the Devil Room. Collecting more than one Guppy will not add any more lives if the player already has nine, but will reset your max health back to one Heart Container.

When you get additional Heart Containers, your Heart Containers will reset to one after your first death.


Familiar: Follows the player.


Dessert Icon

Increases available Heart Containers by one.

Boss Room drop.

No visual effect. (A,6,3)


Dinner Icon

Increases available Heart Containers by one.

Boss Room drop.

No visual effect. (A,5,3)

Distant Admiration

Distant Admiration Icon

A red attack fly circles further out than the Halo of Flies/Pretty Flies, but closer than Forever Alone.

The attack fly can deal damage to all enemies, unlike the other flies which can only block shots and hurt enemy flies.

Deals more damage than Pretty Fly/Forever Alone.

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Orbit: Circles around the player.

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Demon Baby

Demon Baby Icon

Follows Isaac and automatically fires short range shots from any angle at enemies near you. Does not shoot if there are no enemies in the room or none in range. Does not shoot across holes in its range.

Confirmed to take on the effects of the player's own projectiles, like the Spider's Bite's slowing effect and Mom's Contacts' freezing effect.

Unlocked by completing Sheol with Eve.


Familiar: Follows the player.


A Dollar

A Dollar Icon

Sets your coin count to the maximum of 99.

The A Dollar and Blood Bag rewards can be "re-rolled" with The Dice.

A final reward from Slot Machines; they come out when the machine explodes from overuse (rarely).

Automatically unlocks Cain.

No visual effect. (A,9,2)

Dr Fetus

Fichier:Dr Fetus Icon.png

Replaces Isaac's shot with a bomb. Only one bomb can be shot at a time, and it will slide a fixed range before exploding. The bomb slides over pits, and can be pushed around. Bombs detonate faster as the Tears stat increases.

    In the Wrath of the Lamb   expansion, when combined with Mr.Mega the bombs gains the  huge troll bomb look.

Substantially increases the likelihood of bomb-related upgrades.

The Bobby-Bomb and Mr. Mega upgrades improve Dr. Fetus bombs as well.

(Other synergies available on the Item Synergy page.)


After Globins collapse in a pile and then revive, the bombs will pass through them, making them much harder to hit.

Unlocked by completing the game five times.

A rare find in the Item Room.

When fired and shot at by Little Gish, the bombs will appear black and may slow any surviving enemies.

With the Lump Of Coal, the bombs turn completely black.

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Isaac sports the familiar top hat and monocle of Dr. Fetus from Super Meat Boy, another game made by Edmund McMillen.


Forever Alone

Forever Alone Icon

Spawns a blue attack fly that orbits a long distance from Isaac.

Doesn't deal as much damage as Distant Admiration.

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Orbit: Circles around the player.

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Guardian Angel

Guardian Angel Icon

Spawns a guardian angel that orbits Isaac. Does damage on touch similar to other orbitals.

This will also cause all orbiting items/familiars (Pretty Flies, the Cube of Meat, Distant Admiration, Forever Alone, and the Guardian Angel itself) to orbit at roughly double speed.

Unlocked by completing Sheol with Maggy.

Found in the Item Room and Angel Room.

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Orbit: Circles around the player.

Trivia: The misspelling of 'Guardian' within the game ("Grauniad") is a reference to the British newspaper "The Guardian"'s tendency to make typographical errors, a joke popularized by "Private Eye".


Growth Hormones

Growth Hormones Icon

Increase Speed and Damage by two each.


The growths remain pink when Isaac's body is turned into another color due to color-changing items.

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Issac receives inhuman growths on his head.

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The Halo

The Halo Icon

Increases all stats except range by one.

Unlocked by defeating either Mom or Mom's Heart by using The Bible.


Can also be collected before unlocking it if you get teleported to the Angel Room and the Angel Room contains it.

Found most common in the Item Room.

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Isaac sports a halo.

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Halo Of Flies

Fichier:Halo Of Files Icon.png

Grants two Flies that circle Isaac, blocking enemy shots that hit them. These kill other flies that touch them but do not damage other enemies.

Can stack with a Pretty Fly/Cube of Meat/Guardian Angel/Itself up to a maximum of three. Flies have the lesser priority regarding orbitals and are replaced by other orbitals when all three "orbital slots" are taken. Flies cannot replace other orbitals and nothing happens if picked up when already having three.

Found in the Item Room.

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Orbit: Circles around the player.

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The Inner Eye

The Inner Eye Icon

GivesIsaac a triple shot, sets Tears to minimum (rate of fire).

Chocolate Milk allows the triple shot to be fired more quickly for lower damage.

(Other synergies available on the Item Synergy page.)

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Isaac gains a third eye.



The Ladder

The Ladder Icon

Allows Isaac to walk across gaps one square wide by automatically placing a ladder between the two walkable areas (or between walkable area and room wall).

It also confuses the pathfinding of all non-flying enemies. For example, Globins /Gapers will lose you and stop if you are standing over a gap. This is very useful against all non-shooting, non-flying monsters.

Note that this item is only useful in levels three to six as later levels do not have pits.


It is possible to get stuck if you use the ladder to walk onto a tile surrounded by pits with a Stone Grimace or Vomit Grimace. One can also get stuck by quickly moving onto a tile with a Stone Grimace or Vomit Grimace surrounded by pits, as the player will be pushed and trapped between two of them.

This item is fairly common in Shops.

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No visual effect on the character, but the ladder appears beneath them when crossing gaps.

Little C.H.A.D.

Fichier:Little CHAD Icon.png

Drops a half-heart upon completion of every two rooms.

Useless to ???.


If the player already has Little Steve, Sister Maggy or Little Gish at the time of collecting Little C.H.A.D., Little Steve/Sister Maggy/Little Gish will be transformed into Brother Bobby for the duration of the room.

Unlocked by killing the alternate boss C.H.A.D.


Familiar: Follows the player.


Little Chubby

Little Chubby Icon

Adds a small grub that follows Isaac.

Charges forward and deals touch damage to any enemies in his path. Will attack when the player attacks with a moderate cooldown time before he can attack again.

Chub's attack is affected by momentum, just as tears are. Thus, he can be shot diagonally.

Although Little Chubby has an enemy penetrating effect it will not damage Knights from the front like Cupid's Arrow or Technology will.


When you enter a new room, the first shot will automatically activate Little Chubby.

Unlocked by defeating all of the Caves bosses.


Familiar: Follows the player.

Little Gish

Little Gish Icon

Follows Isaac around shooting tar projectiles that reduce enemies' movement speed, shot speed, and range for 2.5 seconds.

Unlocked by killing Gish. Will always be dropped after killing Gish. (Can also be found in a Treasure Room)

Familiar: Follows the player.


Little Steve

Fichier:Little Steve Icon.png

Follows Isaac around, shooting homing projectiles.

The Dice CAN be used after the boss fight with the alternate boss Steve to give Steven instead of Little Steve, and vice versa. However the drop rate of Steven from Steve is very low, re-rolling most likely gives you Little Steve again.

Unlocked by killing the Steve alternate boss and is dropped after the boss fight. Can also be found in Item Rooms.


Little Steve might turn into Brother Bobby in every new room until you get harmed.

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Familiar: Follows the player.

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Loki's Horns

Fichier:Lokis Horns Icon.png

Grants a random chance for projectiles to fire in a plus (+) pattern. This chance is increased with your Tears stat.

If the player has Mom's Eye and The Inner Eye, the plus shot is always fired.

If the player shoots a charged Chocolate Milk shot, all of the cross pattern shots will be charged.


Sometimes it may appear before being unlocked.

Unlocked by defeating all of the Depths bosses.

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Isaac gains small horns.


Lord Of The Pit

Fichier:Lord Of The Pit Icon.png

Isaac can fly over all obstacles, including damage floors, spikes, rocks, and pits. (Same effect as Transcendence, but with different visual effects).

A useful technique when you have acquired Lord of the Pit is to hover over a pit and shoot at walking enemies like Globins and Gapers. These enemies cannot get to you as long as you are above the pit.

Can be found in the Devil Room and after fighting The Fallen.

Trivia: There is an error in the spelling for the effect. It is quoted as "Deamon Wings". (This is a spelling error, but also might be an attempt at the old English spelling of the word, which is "daemon".)

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Grants the player demon wings and turns the player's entire body black.


Lucky Foot

Lucky Foot Icon

All pills picked up will have positive effects (same effect as the PHD but without pill identification). Increases the chance of getting items from poop piles and fires. Increases the chance of winning the Skull Challenge in the Arcade room from 33% to 50%. Increases the chances of getting items from Gold Chests.

As of WotL expansion v1.48, it reduces the chance of getting random fortunes from the Fortune Telling Machine, and increases the chance of getting rewards from it.

Cain starts the game with this item.

Found in the Item Room, the Boss Room and Devil Room.

Unlocked by collecting 55 coins in one playthrough.

Fichier:IsaacLucky Foot Icon.png

Creates a gold anklet on Isaac's left foot.



Lunch Icon

Increases available Heart Containers by one.

Boss Room drop, and can be obtained from Beggars.

No visual effect. (A,4,3)

A Lump Of Coal

Fichier:A Lump Of Coal Icon.png

Increases damage based on how far tears have traveled (tear size increases as it gets farther away).

If A Lump of Coal is "rerolled" with the The Dice, it may be replaced by other Devil Room items. In this case, the item will not cost any Heart Containers.

Dropped after fighting Krampus.

Fichier:Isaac Lump of Coal.png

Coal dust on forehead. Tears are stained black.


Magic Mushroom

Magic Mushroom Icon

Fully heals Isaac, increases all stats by one (including available Heart Containers) and increases tear size.

Will give ??? a Soul Heart instead of healing.

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Player becomes visually larger.

A reference to the "Super Mario Bros." series.



Magneto Icon

Attracts coins, bombs, hearts and keys towards Isaac from a set distance (about seven to eight tiles). Objects can cross pits, spikes, and rocks. Will not draw in hearts if health is full.


It will also attract Troll Bombs towards Isaac.

Magneto will only attract eternal hearts when health is not full (Like red hearts).

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Isaac has a magnet on his head.

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The Mark

The Mark Icon

Increases Damage by one and Speed by two. Adds one Soul Heart.

Will kill you if you have two or less Heart Containers when you make the devil deal despite giving you one Soul Heart.

Available by defeating The Fallen or traded in a Devil Room.

Also found in the Curse Room.

From the Book of Revelations: "And I saw thrones, and they sat upon them, and judgment was given unto them: and I saw the souls of them that were beheaded for the witness of Jesus, and for the word of God, and which had not worshipped the beast, neither his image, neither had received his MARK upon their foreheads, or in their hands; and they lived and reigned with Christ a thousand years." (quote 20:4).

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Isaac sports three 6's in a circular pattern.


Max's Head

Fichier:Maxs Head Icon.png

Increases damage by one, increases the size of tears and causes tears to inflict more knockback on enemies.


Even though it only appears to increase damage by one, a single tear will kill attack flies, and kill Pooters and Horfs in two hits.

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Isaac's eyes grow bigger and more shiny.


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Mini Mushroom

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Increases speed and range by one.

Shrinks Isaac's hitbox, making dodges easier.

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The player's size decreases.

Reference to "New Super Mario Bros. DS"

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Mom's Contacts

Fichier:Moms Contacts Icon.png

Grants Isaac a petrifying shot that will randomly freeze enemies solid for 2.5 seconds and turns tears bright red.

If the body of a Mr. Maw enemy is frozen when the head launched, the head will detach but then reattaches when the body is unfrozen.


The freezing effect will not work on Mom, but it will work on It Lives and invulnerable enemies (Statues in The Depths, Knights attacked from the front, etc).

Unlocked by collecting Mom's Eye and any other Mom's item on the same run.

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Isaac gains a red eye.


Mom's Eye

Fichier:Moms Eye Icon.png

Increases Tears stat and gives Isaac an eye on the back of his head, allowing you to shoot in both directions at the same time.

The shots from the back fire at random, so having a faster firing rate means a more common multi-shot.

Fires normal tears, even when used in combination with items like Technology.

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Isaac gets another eye on the back of his head.

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Mom's Heels

Fichier:Moms Heels Icon.png

Increases Range by two.

Boss Room drop or rarely in the Item Room.

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Isaac wears mom's shoes.


Mom's Knife

Fichier:Moms Knife Icon.png

Once collected, Isaac no longer shoots tears, he shoots the knife from his mouth boomerang style. The range of throw increases by charging the shot. It can also be shot diagonally by using two arrow keys. Mom's Knife passes through enemies on its arc.

Can also be used as a melee weapon, in which case it does high damage and possibly instantly kills any enemies that its edge touches.

It is possible through the use of two or more range down pills to make it impossible to throw the knife, effectively resulting in a forced melee mode.

The knife is tied to your base damage and shot effects (e.g. spider bite or chocolate milk).

Having collected the Common Cold covers the blade in poison, to the point where it drips to the ground. Tints the blade yellow when Number One is collected. Also tints the blade ghostly grey when the Small Rock is collected. If you pick up the Ouija Board, your blade will become transparent.

When using My Little Unicorn (or the VII Chariot tarot card) the knife does not disappear, allowing you to stab, throw the knife, and charge around at the same time.

When the Candle is used with a Wiggle Worm Knife, the knife stalls in the air when thrown or used when walking.

(Other synergies available on the Item Synergy page.)

Using the mouse to attack will not allow you to shoot diagonally.

Unlocked by beating Sheol with Isaac.

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Isaac wields mom's knife and wears her dress.


Mom's Lipstick

Fichier:Moms Lipstick Icon.png

Increases Range by one.

Found in the Boss Room or rarely in the Item Room.

Fichier:Mom's Lipstick.jpg

Isaac wears mom's lipstick sloppily.


Mom's Underwear

Fichier:Moms Underwear Icon.png

Increases Range by one.

Found in the Boss Room or rarely in the Item Room.

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Isaac wears Mom's panties.


Money = Power

Fichier:Money Equals Power Icon.png

Increases damage based on the number of coins the player has at the moment. (10 coins = one extra damage, for a maximum of almost +10 damage).

Found in the Item Room or Devil Room.

Unlocked by completing the game eight times.

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Isaac gets awesome dollar-sign glasses.

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Mr. Mega

Fichier:Mr Mega Icon.png

Gives Isaac five bombs, and makes all dropped bombs large bombs (the same sized bomb dropped when Mr. Boom is used). Increases the damage of bomb, noticeable in boss fights.


If the player has the Dr. Fetus powerup (converting your shots to bombs) then it also applies to those bombs.


When combined with the Bucket of Lard powerup, causes a flicker effect on the character (because to overlapping textures).

Unlocked by using 100 bombs.

Found in the Item Room, and Shops

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Gives the player a helmet/facial expression similar to Wrath, who in turn is a reference to "Bomberman".

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My Reflection

My Reflection Icon

Gives Isaac's tears a boomerang effect and range is set to default range.


Any additional range adds to the distance of the boomerang effect. However it ultimately limits your prime range to medium. Flinging the shots by firing while walking forward drastically improves the maximum distance they will travel with this upgrade. The shots are actually drawn to your current location, meaning that you can 'pull' them in a direction by walking that way. This also means that if they go through you, they will turn around and start heading back again, etc until they reach their maximum range or hit something.

Bad in conjunction with Ipecac.

Works well in conjunction with Ouija Board, Cupid's Arrow, The Inner Eye, Lump of Coal, and/or Spoon Bender.

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Isaac gains a Sailor Moon type symbol on his forehead.


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Number One

Number One Icon

Sets Isaac's tears to their maximum rate of fire and minimum range.


Collecting The Mark (and maybe other tear-changing items) before collecting Number One increases your rate of fire to max, but doesn't decrease your range.

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Isaac stops crying and smiles while yellow colored projectiles (urine) come from his lower body rather than his face.


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Odd Mushroom (Thin)

Odd Mushroom (Thin) Icon

Increases speed by one, increases Tears to maximum (rate of fire) while reducing projectile damage by one.

Found in the Item Room and Shops.

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Makes player's head smaller.

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Odd Mushroom (Large)

Fichier:Odd Mushroom (Large) Icon.png

Increases damage by one, and increases maximum Heart Containers by one while reducing speed.

Found in the Item Room and Shops.

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Makes player's head bigger.

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Ouija Board

Ouija Board Icon

Allows Isaac's shots to go through rocks or obstacles, but unlike other piercing upgrades; will not pierce enemies and will not damage Knights from the front.

Shots will be stopped by stone-turret-heads, but they will be moved by the shot.

Tears go through fire, poop, TNT barrels and extinguish/destroy/detonate them at a slower rate than usual (unless combined with Technology, in which case they're all destroyed instantly). Familiars' shots are not affected by some of these changes. For instance, Brother Bobby's tears will still put out fires. Also works with Dr. Fetus upgrade.

Available in the Devil Room, Item Room or from Beggars.

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Makes Isaac's head look undead or soulless.


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The Pact

The Pact Icon

Increases Damage by one and rate of fire by two. The player also gains two Soul Hearts.

If you have Transcendence when you pick up The Pact, you will have a body again, but with demon wings like the Lord of the Pit item grants.

Available by defeating The Fallen or traded in a Devil Room.

Fichier:Thepact Isaac.png

Turns the player's body black, gives him small horns, and makes him seem more aggressive.


The Parasite

The Parasite Icon

Makes the Isaac's tears split in two when they hit something. Sets firing rate to one. Stains tears brownish-orange.


Tears only split when they stop. That means with piercing upgrades (i.e. Cupid's Arrow or Brimstone) they won't split on enemies.

Unlocked by collecting two "dead things" (Bob's Rotten Head, Guppy, Max's Head, Tammy's Head) in a single playthrough.

Fichier:Parasite isaac.jpg

A creature appears on Isaac's head that looks like the Parasite from the Flash-Game "The Visitor" by Zeebarf.




Pentagram Icon

Increases Damage by two. Increases chance for a Devil Room to appear.

Found in the Boss Room.

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Isaac grows large horns.



PHD Icon

Changes the effects of the Health Down pill to Health Up, Tears Down to Tears Up, Speed Down to Speed Up, Range Down to Range Up, and Bad Trip to Full Health. This also restores three Heart Containers on pick up. Reveals pill names five seconds after picking up the pill.

Will not change pills that have been dropped beforehand.

Also increases coin payout from the Blood Donation Machine from 1-3 to 2-4.

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Isaac wears a doctor's mask.

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A Quarter

A Quarter Icon

Gives you 25 coins.

If seen in the Shop, always buy it if possible as you will make a profit.

Sometimes found in Item Rooms. Found in Devil Rooms costing either one heart  container or three Soul Hearts. Can be dropped by Super Greed.

Unlocked after beating the game four times.

No visual effect. (A,10,2)

Raw Liver

Raw Liver Icon

Increases available Heart Containers by two and fully heals the character you're playing as.

Primarily found in Secret Rooms. A rare drop from bosses or Gluttony.

No visual effect.

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The Relic

The Relic Icon

Isaac is followed by a small blue cross that will drop a Soul Heart upon completion of every fourth room.


Turns Little Steve, Little Gish, Sister Maggy and/or Robo-Baby into Brother Bobby for the current room when collected.

Unlocked by completing The Womb with Magdalene.


Familiar: Follows the player.

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Fichier:Robo-Baby Icon.png

Follows Isaac around, shooting enemies with an eye laser similar to those from Technology.


When the Robo-Baby shoots his laser at the same time with monstro II's beam, it makes the laser larger but no change in damage.

Unlocked by completing The Womb with Judas.


Familiar: Follows the player.


Roid Rage

Roid Rage Icon

Increases Speed and Range significantly.

Found in Challenge Rooms, Item Room and Shop.

Trivia: This item's name, appearence and effect are taken from an item from The C Word, another of Edmund McMillen's games.

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Isaac gets crazy looking.

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Rosary Icon

Increases Faith by adding three Soul Hearts and increases the chance for a Bible to appear in the subsequent levels of the playthrough.

Found in Item Room and Shop.

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Isaac has a cross amulet.

Rotten Meat

Rotten Meat Icon

Increases available Heart Containers by one.

Found in the Boss Room and Gold Chests.

No visual effect. (A,8,3)

Sack Of Pennies

Fichier:Sack Of Pennies Icon.png

Isaac is followed by a small bag that drops a coin upon completion of every two rooms. Usually a penny, sometimes a nickel.


If you already have Little Steve with you when you pick this up, he will bug out and turn into Brother Bobby until you leave the room.

Unlocked by completing The Womb with Cain.

Familiar: Follows the player.


The Sad Onion

The Sad Onion Icon

Doubles the Tears stat (rate of fire).

More commonly found in Chests.

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Isaac begins to cry much harder.

Trivia: Possibly a reference to a running gag from Ashens' videos.


Sister Maggy

Sister Maggy Icon

Follows Isaac around while shooting blood tears.

More powerful than Brother Bobby. (Blood tears deal more damage than normal tears.)

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Familiar: Follows the player.



Fichier:Skatatole Icon.png

All the various fly type enemies no longer harm you, shoot, or split.


Boom Flies will still be harmful, but their speed is reduced. Suckers will also still fire their shots when they die. An attack fly that has newly spawned will still need to 'convert' into a simple black fly, and touching it will damage you.

Final reward for the Shell game in the Arcade Room.

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Isaac supports a pile of poop on his head.


Skeleton Key

Fichier:Skeleton Key Icon.png

Sets your key count to the maximum of 99.

Found in the Item Rooms and Challenge Rooms.

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A keyhole appears on the player's forehead.

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Small Rock

Fichier:Small Rock Icon.png

Increases damage by two, increases tears by one, decreses speed by one, and turns tears grey.

Found in X Rocks.

Unlocked by bombing 50 rocks.

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Isaac has a rock wedged in his head.

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Spelunker Hat

Spelunker Hat Icon

Reveals the Secret Room and Top Secret Room when passing by it and reveals if a room contains a mini-boss.

Unlocked by completing the Caves.

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Isaac wears a miner's helmet.

Spider's Bite

Fichier:Spiders Bite Icon.png

Gives Isaac's shots a chance of slowing enemies for 2.5 seconds. The projectiles from a slowed enemy are also slowed but retain their air time, effectively reducing their range. Turns tears white.


This will work against statues in The Depths and against Knights from the front.

This item will only appear in a Secret Room.

Unlocked by completing the Basement .

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Isaac has a red "bite mark" on his head.



Spoon Bender

Spoon Bender Icon

Gives the Isaacs's shots the ability to curve towards enemies and turns tears purple.


This does affect Technology visually, but has no actual effect.

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Isaac gets a flaming, psychic third eye.



Steam Sale

Steam Sale Icon

Reduces all Shop prices by 50%, rounded down (in the case of collectable or activated items) or rounded up (in all other cases). Will affect items that were already on sale before obtaining this item.

Occasionally dropped by Greed or a Beggar and can be bought in Shops.

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Isaac gets a price tag.



Fichier:Steven Icon.png

Increases damage by two.

If you already have Little Steve and you fight the special Steven boss, he will drop this instead. There is also a chance to get Steven without Little Steve.

Using The Dice with Little Steve after Steven boss fight will have a small chance to change it to Steven.

Trivia: A cameo from another of Edmund's game, Time Fcuk.

Dropped by Steven. Can also be found rarely in Golden Chests (even before unlocking him as a boss).

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Isaac gains a little tumor buddy that smiles.


Super Bandage

Super Bandage Icon

Increases available Heart Containers by one and gives two Soul Hearts.

Rarely found in Boss Rooms.

Also makes a unique sound on pickup.

Unlocked by beating four harbingers' in one playthrough.

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Isaac gets things like a bandage and a flower. Resembling Bandage Girl.

Trivia: This is a reference to "Bandage Girl" from "Super Meat Boy", another game Edmund McMillen worked on.



Technology Icon

Gives Isaac a laser shot with unlimited range. Shots pierce enemies but not rocks, fire, or poop. Shots can't be angled, and will not provide knockback. Shots come from Isaac's left eye only (so if you aim up, they are to the left, down they are to the right, left they are below your aim, and right they are above it).

If A Lump of Coal is picked up after technology, damage is increased. (Maxed?)

When combined with Polyphemus or Mutant Spider, it creates a large laser that does Maximum damage, but can only be fired periodically (about 1.5 seconds in between shots).

When combined with Sacred Heart, the laser will turn purple and does more damage. The white eye effect on Isaac is cancelled.

(Other synergies available on the Item Synergy page.)


Isaac gets a cyborg eye.




Transcendence Icon

Removes Isaac's body, allowing flight over obstacles, spikes and pits.

If you have an upgrade which makes your player's body look demonic (like The Pact or The Nail), Transcendence will give you black demon wings instead of simply removing the character's body. This happens regardless of whether the demonic item is acquired before or after Transcendence.

This item appears only in Secret Rooms.

Unlocked by completing the game two times.

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Isaac becomes a floating head.


Treasure Map

Treasure Map Icon

Reveals all rooms for every floor, including the Secret Room. However, it does not reveal icons.

If you only have The Compass and see a mini-boss icon, you are sure to meet Greed there if you collect the map and it shows the secret room at this point.

Common in Shops and occasionally found in Challenge Rooms. Often given by Beggars.

No visual effect. (A,1,7)

The Virus

The Virus Icon

Gives Isaac the ability to deal damage to, and poison, enemies they touch for 2.5 seconds. The player will still take damage from touching enemies, but remember that not every enemy can hurt you by touch!

Small black flies (not the flashing ones) can be killed by running into them without taking damage.

This item is sometimes dropped by Lust, or found in the Challenge Room.

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Isaac becomes diseased.

The Wafer

The Wafer Icon

Reduces all damage received by half, rounding up to the nearest half-heart. This includes the damage received from using a Blood Donation Machine in The Womb.

Unlocked by completing the game seven times.

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Isaac starts glowing around his head.

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Whore of Babylon

Whore Of Babylon Icon

If you have a half-heart left, a message reading "What a horrible night to have a curse..." appears on the screen and the player becomes the Whore of Babylon. This increases Isaac's damage by three and speed by two and he will stay in that form until leaving a room with more than a half-heart.


If ??? picks this up, he permanently gains its effects upon leaving the room for the remainder of the game.


Avoid buying it while having plenty of Soul Hearts and only one red as it will leave you with no hearts at all and you'll die on first hit.


Edmund McMillen (the creator) has stated that Whore of Babylon and similar items are damage multipliers.

Eve starts the game with this item.

Found in the Devil Room, Item Room or after defeating The Fallen. Might appear in the shop for two Heart Containers or 15 coins as well.

When activated while the player has Fate, the Holy Grail, or the Bible activated, the wings turn black.

Isaac becomes a spawn of Satan.

Trivia: The pop-up message when activated is a reference to the NES game "Castlevania 2: Simon's Quest", when nightfall comes.

Wiggle Worm

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Gives Isaac waving shots and increases attack speed by one, these do not angle with movement.

May increase homing effect for homing tears.

Found in the Shop or Item Room.

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Isaac's eyes shrink and become jittery.

Wire Coat Hanger

Wire Coat Hanger Icon

Increases Tears by two.

Found in the Boss Room.

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Isaac gets a coat hanger through his head.

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Wooden Spoon

Wooden Spoon Icon

Increases speed by two.

Found in the Boss Room and Gold Chests.

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Isaac has beat marks from a spoon.

X-Ray Vision

Fichier:XRay-Vision Icon.png

Reveals and opens Secret room entrances.

This is an exceptional item early on, as it allows access to every secret room without the need for bombs.


This can create exits from the Secret Room that are normally not possible, such as exiting into a Boss Room.

This item can be exploited to indefinitely recharge items with the Battery by entering and leaving a room with enemies without clearing it as needed.

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Isaac wears X-Ray glasses.

Trivia: The effect is described as "I've Seen Everything," a reference to Patrick Stewart's appearance on British sitcom "Extras" alongside Ricky Gervais.

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Wrath of the Lamb Collectible ItemsModifier

The following collectible items can only be acquired if you have the Wrath of the Lamb expansion.

Name and Icon Effect Info Collection Grid (Pg,X,-Y)

3 Dollar Bill

3 Dollar Bill Icon

Effect given changes every room. It can give you the effect of: Mom's Contacts, My Reflection, Number One, Ouija Board, Spoon Bender, The Inner Eye, Tough Love and Magneto (via bug).

Since it can grant the Magneto effect, it can be used to aquire items (bombs, keys etc.) you otherwise couldn't, by repeatedly leaving and re-entering a room.

Also a very bad synergy caused by My Reflection effect from 3 Dollar Bill with Ipecac. It causes Ipecac shots to follow the player until they hit an obstacle or wall.

The name most likely comes from the slang "Queer as a three dollar bill".


Isaac appears to be happy. Stars appear around his eyes when he fires tears.



Abel Icon

Mirrors Isaac's movements. Shoots in opposite direction to the player. (Basically, a friendly Dople.)


When combined with Holy Water, the Holy Water will assume Abel's movements and Abel will follow you as a normal familiar.

Unlocked by completing the Cathedral as Cain

Fichier:Isaac Abel.png

Follows The Player.




When killed, respawns in the previous room as ???, regardless of the fact he is unlocked or not. After respawn, all future Heart Container upgrades will be Soul Hearts only. Only works once.

If you are playing as ???, and you are wearing this when you die, you're simply revived in the previous room with 3 Soul Hearts (similar to 1UP).

(If you defeat any end game bosses, you will have the achievements from ??? instead of your first character, although if you die; it shows the name of your original character).

The Ankh triggers before 1UP.


With the Dead Cat item, if you die as ??? you will respawn as your previous character with 1 Heart Container.

The Ankh effect will occur before the effect of the Dead Cat, so you will first respawn as ??? before using up any of the 9 lives obtained via the Dead Cat.

If the ??? boss is killed by ??? made using the Ankh (from Isaac), the game gives you Eve's Bird Foot and Steam gives you "Samson's Lock achievement". (bug)

Fichier:Isaac Ankh.png

Isaac wears an ankh around his neck and gets a slight eye shadow.


The Black Bean

The Black Bean Icon

When taking damage, Isaac farts, causing poison damage to all enemies in range. Same as Bad Gas pill.

Fichier:BlackThe Bean Icon.png

Fatter, as with Bucket of Lard, but with a slightly darker hue.

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Bloody Lust

Bloody Lust Icon

Increases damage each time Isaac kills an enemy for the current room. Isaac and his tears turn red with more power gained.

Samson starts with this item. Some enemies, such as Globin, and some bosses, such as Larry Jr, will increase damage during the battle as their healths are "tiered" to each other.

When used with Chocolate Milk, charged shots are smaller and weaker.

"MEAT!" and "Toothpicks" do not increase tears when Bloody Lust has been collected beforehand.

Can be used in conjunction with The Necronomicon to build power by destroying enemy shots.

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Isaac wears a red bandana.

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Bob's Curse

Fichier:Bobs Curse Icon.png

Gives five bombs and grants all bombs poison effect. This includes bombs fired from Dr. Fetus, Missile from Epic Fetus, Best Friend decoy, enemy bombs, troll bombs and TNT barrels.

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Isaac's head appears diseased. Bombs turn into Bob's Rotten Head, with no fuse.

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Box Icon

Spawns one of each item: one coin, one key, one bomb, one heart, one tarot card, one pill, and one trinket.

Decreases speed by one.

Variants of each item (such as nickels and troll bombs) may also spawn instead

A drop from common bosses.


Regular or half hearts never drop, only Soul and Eternal Hearts.

Fichier:Isaac Cardboard Box.png

Isaac wears a box around his torso and when turned sideways the box says "Isaac".


Bum Friend


Portable beggar that picks up coins for itself to use when you are not in battle. After getting random amount of coins, he drops a pickuppickups (includes trinkets). If he gets a dime or nickel, it will be counted as getting multiple coins in a row, so he will probably drop multiple pickupspickups (includes trinkets). Doesn't drop collectiples.

Reverts Little Steve, Robo-Baby, Rainbow Baby, and Little Gish to Brother Bobby. Getting Brother Bobby will change your familiar back to its normal form.

Pushes your bombs.

Fichier:Isaac Bum Friend.png

Familiar: Follows the player.



Tears will travel faster. Bonus does not stack with Speed Ball.

Found in the Boss Room.

When used in conjunction with Brimstone, the amount of time the laser is fired for is lessened (meaning less damage potential), without any real plus.

Fichier:Isaac Cat-o-nine-tails.png

Isaac recieves large cuts all over his face.


Celtic Cross

Celtic Cross Icon

Small (30%) chance to cast the Book of Shadows shield on Isaac upon taking damage.

Works well in conjunction with the IV Bag, which will provide coins at no health cost while the shield is up.

Unlocked by completing the Cathedral as Magdalene


A celtic cross circle appears behind Isaac's head.


Chemical Peel

Chemical Peel Icon

Tears fired from left eye (side of face that is peeled) do increased damage. This stacks with the damage increase from The Peeper.

Does not work in conjunction with Mutant Spider.

When used with Cain, tears will randomly do increased damage.


Half of Isaac's face is burned off leaving muscle similar to Dople

Possibly a reference to the "Batman" villain, Two-Face.

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Daddy Longlegs


Daddy Long Legs' shadow follows player and stamps on enemies. The leg does not hurt the player.

In some situations, Daddy Long Legs will be replaced with Triachnid's leg.

During the fight with Isaac, he will only stomp the boss once and won't come down again until Isaac has been defeated.


Shadow follows the player.


Dead Dove

Fichier:Dead Dove Icon.png

Gives Isaac spectral tears and flight.

Found in Item Room, Angel Room and Library.

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Isaac's body becomes a phantasmic aura, and his face turns soulless.


Epic Fetus


Tears become guided missiles (See The Doctor's Remote item). Locks firing rate (including that of multi-shot effects like Mom's Eye) to the time it takes for the missile to strike and detonate. Overrides Dr. Fetus and Mom's Knife. Use the mouse for convenience. Usually found in the Secret Room.

Bob's Curse makes green explosion when the missile lands but the poison effect doesn't work like the Common Cold and Dr Fetus.

(Other synergies available on the Item Synergy page.)

Unlocked by completing the "The Doctors Revenge!" Challenge.


If used when Mom's Bra is in effect the aim will freeze after a very short time, causing the player to be unable to move the crosshair.

Fichier:Isaac Epic Fetus Icon.png

Isaac looks like he would with Dr. Fetus, just with an angry eyebrow over the monocle.



Fate Icon

Isaac gains flight and an Eternal Heart.

The sprite is actually from Edmund's 'DeadBaby VG Dressup' game on New grounds. It appears on the Dead Baby and in the background of the loading / menu screen.

Rarely found in Golden Chests.

Isaac grows angelic wings.


Ghost Baby

Ghost Baby Icon

Familiar that shoots spectral tears.

If you have Spider's Bite, Ghost Baby's tears can also inflict the slowing effect.

Fichier:Isaac Ghost Baby.png

Follows the player.

Guppy's Hair Ball


Loosely follows behind Isaac. Can be swung like a flail by rapidly spinning Isaac in a circle.

Deals damage when it collides with enemy units. If an enemy unit is killed by the ball it increases in size up to a maximum limit. The larger the ball becomes the easier it is to swing, the larger its collision circle becomes, and the higher its damage becomes. Size is reduced at the start of each floor.

Unlocked by transforming your Character into Guppy. Achieved by collecting three Guppy items in one playthrough (any combination of Guppy's Tail, Dead Cat, Guppy's Head, and Guppy's Paw. You don't need to keep the Paw or Head, just activate it at least once).

Found in the item Room.

Fichier:GuppysHairball Row.png

Follows the player.


Guppy's Tail


Increases chance of Gold Chests and normal chests.

Also decreases the chance of other normal pickups (not only keys), a reference to the "Cursed?" Caption.

Found in Challenge Rooms, the Devil Room and Red Chests.

When combined with three other Guppy items, Isaac will turn into Guppy. He will also gain the Mulligan effect and the ability to fly.

Fichier:Isaac Guppy's Tail.png

Isaac wears Guppy's tail around his waist.



Habit Icon

When hit, refills some item charge. When used in tandem with healing items such as the Book of Revelations or Yum Heart, it is possible to have nearly infinite life.

Does not refill charge when shielded by the Book of Shadows.


Isaac wears a nun's habit.


Harlequin Baby


Familiar that shoots a pair of tears diagonally every second while Isaac is firing.

Found in the Item Room.

Trivia: This item is based on a real medical condition named Harlequin Ichthyosis that deforms infants, causing them to have scaly skin, a strangely shaped body, and sunken, red eyes and lips.

Fichier:Harlequinbaby ingame.png

Familiar: Follows the player.


Holy Grail

Holy Grail Icon

Adds one empty Heart Container and grants flying ability.
Fichier:Isaac Holy Grail.png

Isaac grows angelic wings and recieves a saint's halo.


Holy Water


The vial will break when Isaac receives damage and a blue spot that damages foes forms, similar to that of Lemon Mishap.

The vial is reformed upon entering a different room.


Reverts Rainbow Baby into Brother Bobby, Robo-Baby into Brother Bobby, Harlequin Baby into Brother Bobby, Sister Maggie into Robo-Baby, Little Gish into Brother Bobby, and Lil Steve into Brother Bobby unless currently broken/spilled (Bug)

Fichier:Holy water.jpg

Familiar: Follows the player.



Infestation Icon

One to three Blue Flies randomly spawn every time Isaac gets hit.

Fichier:Isaac Infestation.png

Isaac becomes infected, his body gets fatter and green with bumps.



Fichier:IPECAC Icon.png

Green projectiles fired from the mouth causing poison/explosive damage. Shots are fired in an arc, so they will fly over enemies unless extremely close (close enough to take damage from the explosion).

Will make Dr. Fetus bombs green and will make the reloading time way longer.

Great interaction with Spoon Bender Sacred Heart or Telepathy for Dummies, and causes shots to home in on enemies and almost never miss.

Fichier:Isaac Ipecac.png

Isaac gets very sick and he spits his projectiles.

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Jesus Juice

Jesus Juice Icon

Pickup description is incorrect, and actually increases damage instead of the tears stat.  (adds 1/2 of your current damage stat)

Fichier:Isaac Jesus Juice.png

Isaac has purple juice stains surrounding the mouth.


Magic 8 Ball


Increases Shot Speed.


Althought the text says "tears up", it does not increase your tears.

Also spawns one tarot card when collected.

Fichier:Isaac Magic Eight Ball.png

Isaac wears the headdress of a fortune teller.



Fichier:MEAT Icon.png

Increases available Heart Containers by one.

Unlisted effect: damage up.


Although the text says "tears up", it does not increase Isaac's tears stat.

Fichier:Isaac MEAT Icon.png

Isaac gets angry with a bulging vein.

(MEAT! is a reference to "Bonk's Adventure" for the TurboGraphix16/PC)



Mitre Icon

Greatly increases the chance of replacing spawned hearts with Soul Hearts.

Stacks with the trinket Mom's Pearl.

Fichier:Isaac Mitre Icon.png

Isaac gains a holy aura.


Mom's Purse

Fichier:Moms Purse Icon.png

Hold one additional trinket.

Commonly found in Shops.

Fichier:Isaac Moms Purse.png

Isaac wears his mom's purse at his side.


Mom's Coin Purse

Fichier:Moms Coin Purse Icon.png

Spawns four random pills around Isaac.

Commonly found in Shops and as a boss drop.

Fichier:Isaac Moms Coin Purse.png

Isaac gains a small coin pouch hanging from his neck.


The Mulligan

The Mulligan Icon

Chance to spawn Blue Flies on successful hits, which charge current target.

If combined with Mutant Spider, will spawn many more flies.

If combined with Technology 2, will spawn many flies because Technology 2 has a very high fire rate.

Named after the enemy of the same name.


When combined with Brimstone, you can't fire.

Blue fly attacks can spawn more blue flies, creating many when on max luck.

Fichier:Isaac The Mulligan.png

Isaac gets fly bites all over his face.

Fichier:The Mulligan Tears.png


Mutant Spider

Mutant Spider Icon

Shoot four tears at once, greatly reduces tear firing rate. Fire rate can still be increased with Tears Up pills and items.

Functions as The Inner Eye when paired with Loki's Horns and Moms Eye, causing Loki's Horns to always fire. Can be combined with Technology 2.

Overrides The Inner Eye.

Fichier:Isaac Mutant Spider Icon.png

Isaac gets two more eyes, as well as two small fangs

Fichier:Mutant Spider Tears.png


Pageant Boy

Pageant Boy Icon

Spawns several coins around Isaac. (May include nickels and dimes)

Chance of spawning coins on being damaged.

A drop from common bosses.

Increases the chance of getting coins from slot machines.

Fichier:Isaac Pageant Boy.png

Isaac wears a pink crown.


The Peeper

The Peeper Icon

Gives Isaac a familiar eye that floats around the room, damaging enemies on contact.

Tears fired from left eye socket do increased damage. This stacks with the damage increase from Chemical Peel.

Floating eye WILL push bombs.


Tears fired from left eye socket do not do increased damage.

Fichier:Peeper visual.png

Isaac loses an eye. Tears from left eye become blood.

(The Peeper is a reference to Peep, a boss in The Caves.)


Polyphemus Icon

Makes Isaac shoot one huge tear, also reduces Tears to minimum. If tear does more damage than an enemy's health, the tear continues to travel with the extra remaining damage.

Note: i

If combined with Cupid's Arrow, shots will turn red and tear size won't decrease if tear does more damage than enemy has health. Tear stays maximum size and pierces enemies.

Stacks with:

Chocolate Milk, and 'Sacred Heart

Inner Eye and Mutant Spider, allowing you to keep your triple or quad shot.

Jesus Juice, damage is maximized and shots turn into blood.

Tough Love. The black eye and swollen mouth will still appear, overlaid on the cyclops eye.

Mom's Eye, making you shoot in both directions on every shot.

The trinket Cancer,  which will do even more damage.


Isaac becomes a cyclops.

The name of this item is a reference to the name of the cyclops from The Odyssey, an ancient Greek epic poem'.




Pyro Icon

Adds 99 Bombs. Can rarely be found in the Secret Room.

Fichier:Pyro action.png

Isaac grows four fuses on his head.


Rainbow Baby

Rainbow Baby Icon

Tear Effect changes every shot.

Effects include split tears, slowing tears, bloody tears, etc.

Unlocked by completing Cathedral as ???

Fichier:Rainbow baby.png

Familiar: Follows the player.

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Sacred Heart

Fichier:Sacred Heart Icon.png

Shots are larger, travel slower and home in on enemies. Damage is multiplied. Decreases Tears by one.

Gives one Soul Heart and restores available Heart Containers fully on pickup. Found in the Angel Room, Curse Room, and as a gift from a Devil Beggar.

When acquired with the Dr. Fetus item, your fetus bombs will follow targets (homing), and regular bombs will also homing affects.

Fichier:Sacred heart Isaac.png

Isaac's eyes glow white, and glowing tears stream down his face.


Sacrificial Dagger


Dagger orbits Isaac, very high damage.

Unlocked by completing the Cathedral as Eve.

Fichier:Isaac Sacrificial Dagger.png

Orbit: Circles the player.



Scapular Icon

Whenever Isaac is downed to one-half of his last Heart Container, the aura around his head temporarily vanishes and he is granted one Soul Heart.

Works differently on ???. When ??? takes damage and he has no Soul Hearts left, he immediately gains one Soul Heart, the aura temporarily vanishes, and recharges upon leaving a room.

With the habit, it can be used to infinitely recharge spacebar items.


If you own the Cursed Skull you'll be invicible against foes except Mom


Isaac has a yellow aura around his head.

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SMB Super Fan!

SMB Super Fan Icon

Increases all stats except Speed by one. Reduces Speed by one.

Unlocked by completing the "Meat 4 Evar!" challenge.

Fichier:SMB Isaac.png

Isaac takes on the appearance of Super Meat Boy, with red skin, chipped tooth, black eye and Isaac leaves a trail of blood where he walks.


Speed Ball

Speed Ball Icon

Increases movement speed and causes tears to travel faster. Tear speed bonus does not stack with Cat-O-Nine-Tails.



Isaac's eyes become dilated, and he has a small grin on his face. He also has a syringe jammed into the back of his head.

Spirit of the Night

Fichier:Spirit Of The Night Icon.png

Grants Isaac flight and spectral tears.

Can be found in the Devil Room.

Fichier:Spirit of the Night Isaac.png

Isaac is black with ghost tail, white eyes and a cool mouth.

This is most likely a reference to the "Magic: The Gathering" card of the same name.


Squeezy Icon

Increases tears by one and spawns two Soul Hearts.

Fichier:Isaac Squeezy Icon.png

Isaac's eyes pop out of his head and has blood around his eye sockets


Stem Cells

Stem Cells Icon

Increases available Heart Containers by one. It also heals a half-heart.

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A fetus grows on the side of Isaac's face.



Stigmata Icon

Boosts Isaac's damage by one and grants you one Heart Container.

Found in the Item Room.

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Isaac has a stream of bloody tears on his face.


Technology 2

Technology 2 Icon

Fires a continuous laser as you shoot tears. Pierces through enemies. When used with Cain, will prevent tears from firing from other eye.

Details here

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Isaac gains a laser-enhanced eye

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Toothpicks Icon

Increases Tears. Range goes down by one and causes tears to travel faster. Turns tears to blood (visual effect only).

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Both eyes are held up with toothpicks, tears become red.


Tough Love

Tough Love Icon

Isaac randomly shoots teeth instead of tears, dealing more than triple damage, the extra damage can go over the damage limit allowing you to deal triple the max damage.

The chance of shooting teeth is related to luck stats, which can be altered with Lucky Toe, Luck Up and Luck Down Pills. With maxed luck stats (9), Isaac always shoots teeth.

When stacked with Mutant Spider or the Inner Eye, more than one shot can be a tooth.

When stacked with Parasite, split shots can also become a tooth.

Contrary to bullet effect, the teeth do NOT have splash effect.

Found in the Item Room.

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Isaac is beaten up.


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Trinkets are a new kind of passive item that were introduced in the expansion Wrath of the Lamb

They provide passive bonuses, but only one can be held at a time. The collectible item Mom's Purse allows two trinkets to be kept at once, even with The Tick trinket. The held trinket is displayed in a slot in the upper left portion of the screen.

Tarot CardsModifier

Tarot Cards (pronounced "ta-roh card") are random items that are either dropped by enemies, found in chests, or spawned in rooms. They are directy inspired by the Tarot of Marseille, and more particularly by its trump cards. They are used by pressing the "Q" key and are one time use only.

You may only carry one card or pill at a time. Attempting to pick up a second card or pill will cause you to drop the one you are currently holding. There are two types of tarot cards in The Binding of Isaac: the Major Arcana and Minor Arcana (also known as deck cards). The Joker is not used in a tarot deck.

Pill EffectsModifier

Pills are random items that are dropped by enemies, found in chests, or spawned in rooms. Pills are consumed by pressing the "Q" key. They come in many colors and the effects change every time you play. Note, the pills DO NOT work like Tarot cards which you can learn the effects of one before use, the color of a pill does NOT foretell its effect in any way. However, if you use a pill and pick up a second pill of identical colors in that playthrough, it will have the same effect as before and its name will be shown, replacing "???". The same goes for additional duplicates you find. de:Old Items page