A six-legged spider with small, red eyes.
Makes a large bite mark come out of Isaac's head.
Gives Isaac's shots a chance of slowing enemies for 2.5 seconds. The projectiles from a slowed enemy are also slowed but retain their air time, effectively reducing their range. Turns tears white.
- Technology - Stacks, and colors the laser pink.
- IPECAC - Stacks.
- Brimstone - Stacks.
- Mom's Knife - Stacks.
- In the Spiderboy Challenge, you start with this item and the Mutant Spider.
- This item is probably a reference to The Amazing Spider-Man, where a spider bite from a radioactive spider gave Spider-Man his super powers.